Lipid Membrane Structure Production by Self-Assembly for Diameter Control
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Solution Overview
Problem
Existing methods struggle to form fine lipid membrane structures with controlled particle diameters using hydrogenated phospholipids, which are required for effective skin permeation and encapsulation of active ingredients, due to high phase transition temperatures and the complexity of refinement processes.
Innovation Solution
A method involving the mixing of hydrogenated phospholipids with a specific compound represented by formula 1 and water, where the concentration of the hydrogenated phospholipid is adjusted to control the particle diameter of the lipid membrane structure, allowing spontaneous formation of structures between 10 nm and 200 nm without the need for refinement means like microfluidizers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrogenated phospholipids are used to form lipid membrane structures, then storage stability is improved, but it becomes difficult to form fine structures with controlled particle diameters
Solution Approach 1:
The invention changes the chemical parameter of the phospholipid by introducing carboxyl groups through controlled oxidation, creating phospholipids with specific acid values (5-50 mg KOH/g). This parameter modification enables the formation of fine lipid membrane structures with controlled particle diameters while maintaining the storage stability provided by hydrogenated phospholipids
Solution Approach 2:
The invention utilizes phase transition phenomena during the oxidation process and subsequent self-assembly of phospholipids. By controlling the phase behavior during oxidation and membrane formation, the process achieves both fine particle diameter control and stable structure formation
2Length of moving object
If refinement means such as microfluidizer are used to form fine lipid membrane structures, then particle diameter is reduced, but device complexity and operation difficulty increase
Solution Approach 1:
The invention enables self-service by designing phospholipids that spontaneously self-assemble into fine lipid membrane structures with controlled particle diameters through their inherent amphiphilic properties and carboxyl group interactions. This eliminates the need for complex external refinement devices like microfluidizers
Solution Approach 2:
The invention replaces mechanical refinement systems (microfluidizers, ultrasonic processors) with a chemical self-assembly system. The controlled oxidation and subsequent spontaneous micellization process substitutes for mechanical size-reduction methods, simplifying the overall device requirements
3Reliability
If concentration of hydrogenated phospholipid is increased to improve membrane stability, then storage stability is improved, but particle diameter becomes difficult to control
Solution Approach 1:
The invention introduces a new controlling parameter - the acid value of phospholipids - which provides a quantitative relationship between phospholipid properties and particle diameter. By adjusting the acid value within specific ranges, both membrane stability and particle diameter uniformity can be controlled simultaneously
Solution Approach 2:
The invention establishes a feedback mechanism where the acid value serves as both a process control parameter and a predictive indicator for final particle diameter. This allows for real-time adjustment and control of particle size while maintaining membrane stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the simple and effective production of lipid membrane structures with targeted particle diameters, enhancing skin permeation and encapsulation efficiency while maintaining stability and uniformity.
Implementation Method 1
a method for producing a composition including: (A) a hydrogenated phospholipid having an acid value of 5 mg KOH/g or more; (B) a compound represented by formula 1... mixing these components to obtain a dispersion in which a lipid membrane structure is spontaneously formed
Data Source
Figure 1(a)~1(b)
AI summary
According to the present disclosure, provided is a means that can control the particle diameter of a lipid membrane structure by a simple method when producing the lipid membrane structure. The present disclosure is a method for producing a lipid membrane structure-containing composition including: (A) a hydrogenated phospholipid having an acid value of 5 mg KOH/g or more; (B) a compound represented by formula 1; and (C) water. The method comprises a dispersing step of mixing the component (A), the component (B), and the component (C) to obtain a dispersion in which a lipid membrane structure having a particle diameter of 10 nm or more and 200 nm or less is spontaneously formed, wherein the dispersing step includes determining the concentration of the component (A) in the dispersion depending on the target particle diameter of the lipid membrane structure included in the lipid membrane structure-containing composition.