Lipid Nanoparticles for Nutraceutical Bioavailability

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Solution Overview

Problem

The delivery of nutraceuticals to the human body is hindered by bioavailability issues due to instability, poor water solubility, and poor distribution in vivo, as many nutraceuticals are unstable and poorly absorbed across biological barriers.

Innovation Solution

A nanoparticle delivery system comprising lipid structural nanoparticles, produced through a sequential process of milling, homogenation, and ultrasonic processing, encapsulating multiple species of nutraceuticals with dissimilar molecular structures using essential phospholipids, fatty acids, and solvents, without the use of heat or polymers, to enhance bioavailability and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If nutraceuticals are delivered in conventional forms, then they are simple to administer, but they have poor bioavailability due to instability and poor water solubility

Engineering Contradiction:

ImprovebioavailabilityVSAvoiddelivery system complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

Lipid structural nanoparticles serve as intermediary carriers that encapsulate nutraceuticals, enabling them to traverse biological barriers. The nanoparticle composition including phospholipids, fatty acids, and solvents acts as a mediator between the nutraceutical and the biological barrier, solving the bioavailability problem without requiring complex external delivery devices

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent transforms nutraceuticals from their conventional physical state into nanoparticle-encapsulated form, changing parameters such as particle size (to nanoscale), solubility (through lipid encapsulation), and stability (through protective encapsulation). This parameter transformation enables poor water-soluble nutraceuticals to become bioavailable while maintaining simplicity in administration

Inventive Principle:

Principle #35Parameter changes

2Adaptability or versatility

If multiple nutraceuticals with dissimilar molecular structures are combined, then the delivery system becomes more versatile, but the formulation complexity increases

Engineering Contradiction:

Improvenutraceutical compatibilityVSAvoidformulation complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The lipid structural nanoparticle delivery system is designed as a universal platform that can encapsulate multiple species of nutraceuticals with dissimilar molecular structures and physical properties. The same basic nanoparticle composition (phospholipids, fatty acids, solvents) serves as a universal carrier for different nutraceuticals, achieving versatility without requiring separate formulations for each nutraceutical type

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent creates a composite nanoparticle system combining lipid structural materials (phospholipids, fatty acids) with various nutraceuticals. This composite approach allows dissimilar substances to be combined in a single stable formulation, as the lipid matrix provides a compatible environment for both hydrophobic and hydrophilic nutraceuticals, reducing formulation complexity

Inventive Principle:

Principle #40Composite materials

3Productivity

If heat or polymers are used in the production process, then the manufacturing may be more efficient, but the stability of nutraceuticals deteriorates

Engineering Contradiction:

Improveproduction efficiencyVSAvoidnutraceutical stability

Core Design Contradiction:

ProductivityVSStability of the object's composition

Solution Approach 1:

The patent replaces thermal processing (heat) with mechanical processing methods including high-pressure homogenization, ultrasonic processing, and milling. These mechanical methods achieve nanoparticle formation and nutraceutical encapsulation without exposing heat-sensitive compounds to damaging temperatures, thereby maintaining nutraceutical stability while ensuring production efficiency

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The production process utilizes parameter changes such as pressure (high-pressure homogenization), temperature (cold techniques), and mechanical energy (ultrasonic vibration, milling) to create nanoparticles. By changing from thermal parameters to mechanical parameters, the process maintains nutraceutical stability while achieving efficient production of the delivery system

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method allows for efficient and stable delivery of nutraceuticals across various biological barriers, including the oral mucosa, ocular, dermal, and blood-brain barriers, improving bioavailability and efficacy while maintaining the stability of the encapsulated ingredients.

Implementation Method 1

The present disclosure teaches a method for nanoparticle assembly comprising three production methods in a sequential process, wherein the three production methods consist of milling, homogenation, and ultrasonic processing

Methodology Applied

Scientific EffectUltrasonic processing: Ultrasound

Implementation Method 2

Methodology Applied

Scientific EffectHomogenation:

Data Source

PatentEP3057604B1Nanoparticle compositions and methods as carriers of nutraceutical factors across cell membranes and biological barriers

Publication Date: 2021.06.09 NANOSPHERE HEALTH SCI INC

AI summary

Novel process and products thereby emplace nutraceutical factors within nanodelivery vehicles for various indications in mammals, including humans.