Lipid-Polymer Particles for Cannabinoid Delivery
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Solution Overview
Problem
Current drug delivery systems for bioactive agents, particularly those with low solubility in aqueous media, face challenges such as stability, degradation, and bioavailability, limiting their effectiveness in treating ophthalmic and dermatologic conditions, including dry eye disease and inflammatory disorders.
Innovation Solution
The development of compositions containing cannabinoids, such as cannabidiol, combined with terpenes and flavonoids, encapsulated in lipid-polymer particles or delivered through pharmaceutical eluting contact lenses, to enhance bioavailability and stability for targeted treatment of ophthalmic and dermatologic conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If liposomes and micellar nanoparticles are used as delivery systems for insoluble bioactive agents, then delivery capability is improved, but stability and bioavailability are compromised
Solution Approach 1:
The patent employs composite lipid-polymer particles that combine the membrane permeability advantages of liposomes with the stability and controlled release properties of polymer-coated nanoparticles. This composite structure resolves the contradiction by integrating multiple material characteristics to achieve both effective delivery and enhanced stability/bioavailability
Solution Approach 2:
The invention modifies the physical and chemical parameters of the delivery system by controlling particle size (10-1000 nm), lipid-to-polymer ratio, and surface charge characteristics. These parameter adjustments optimize both the delivery capability and the stability/bioavailability profile, resolving the technical contradiction through systematic parameter optimization
2Ease of manufacture
If conventional delivery systems are used for bioactive agents with low aqueous solubility, then formulation simplicity is maintained, but bioavailability and treatment effectiveness are reduced
Solution Approach 1:
The patent introduces lipid-polymer particles as an intermediary carrier system that bridges the gap between the insoluble bioactive agent and the aqueous biological environment. This intermediary structure enables effective delivery and bioavailability while maintaining reasonable formulation simplicity through established lipid and polymer chemistry
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compositions provide effective delivery of cannabinoids and other bioactive agents, improving treatment outcomes for ophthalmic and dermatologic conditions by enhancing bioavailability and stability, addressing the limitations of existing delivery systems.
Implementation Method 1
encapsulated in lipid-polymer particles
Implementation Method 2
delivery vehicles including lipid-polymer particles
Implementation Method 3
compositions containing cannabinoids, such as cannabidiol, combined with terpenes and flavonoids
Implementation Method 4
pharmaceutical eluting contact lenses
Data Source
AI summary
The invention provides compositions containing a cannabinoid (e.g., cannabidiol) and optionally one or more bioactive agents for the treatment and/or prevention of diseases including ophthalmic diseases or conditions, dermatologic conditions, infections, inflammatory diseases, and vision disorders. The invention also provides compositions and methods of preparing the compositions containing cannabinoids for cosmetic dermatologic applications and a pharmaceutical eluting contact lens. Furthermore, the invention provides delivery vehicles including lipid-polymer particles and methods of preparing the lipid-polymer particles to deliver the compositions to a subject.