Lipid-Saturated Polymer Matrix for Sustained Drug Release
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Solution Overview
Problem
Current lipid-based drug delivery systems for sustained release in pharmaceuticals face challenges in achieving controlled and extended release profiles, particularly in periodontal and orthopedic applications, where biodegradable polymers have limitations in stability and efficacy.
Innovation Solution
Development of a lipid-based matrix composition using a non-biodegradable polymer in combination with specific lipids and a pharmaceutical active agent, which forms a water-resistant matrix for sustained release, allowing for controlled delivery of drugs like antibiotics, NSAIDs, and osteogenic factors over several days to months.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If biodegradable polymers are used in lipid-based drug delivery systems, then the system is biocompatible and can be metabolized, but the stability and sustained release duration are limited
Solution Approach 1:
The patent combines biodegradable polymers (for biocompatibility) with non-biodegradable polymers (for extended stability and sustained release duration) to create a composite matrix system that achieves both biocompatibility and prolonged drug release over weeks to months
2Object-affected harmful factors
If conventional lipid-based delivery systems are used, then targeted drug delivery and decreased toxicity are achieved, but extended release profiles of days to months are not commonly associated
Solution Approach 1:
The patent creates a composite matrix combining lipid components (for targeted delivery and reduced toxicity) with non-biodegradable polymer components (for extended release duration), enabling sustained release profiles of days to months while maintaining the beneficial properties of lipid-based systems
Solution Approach 2:
The patent modifies the physical and chemical parameters of the matrix system by incorporating non-biodegradable polymers with specific molecular weights and degradation rates, transforming the release profile from hours/days to weeks/months
3Reliability
If systemic chemotherapy or radiotherapy is used for bone tumor treatment, then tumor cells are targeted, but limited ability to eradicate cells and slow bone recovery occur due to limited blood supply
Solution Approach 1:
The patent delivers chemotherapeutic agents and osteogenic factors directly to the bone tumor site through the matrix composition, providing high local concentration at the target site while avoiding systemic circulation limitations, thereby improving treatment efficacy and bone recovery
4Reliability
If immediate infection treatment is provided in orthopedics, then infection control is achieved, but long-term sustained release to prevent complications is not maintained
Solution Approach 1:
The patent incorporates antibiotics into the non-biodegradable polymer matrix that provides sustained release over weeks to months, maintaining therapeutic concentrations at the implant site to prevent both immediate and delayed infections, thereby extending protection duration while ensuring reliable infection control
Data Source
AI summary
The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a block-co-polymers comprising a non-biodegradable polymer and a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.