Liposomal CBD Gummy Delivery Matrix for Bioavailability
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Solution Overview
Problem
Existing gummies containing CBD and other nutrients have low bioavailability due to rapid absorption and clearance from the bloodstream, leading to limited extended presence in the bloodstream and reduced effectiveness.
Innovation Solution
Formulating gummies with CBD incorporated in liposomal vesicles coated with a combination of polyethylene glycol and chitosan, which are surrounded by a free-flowing coating material, enhancing the delivery matrix and increasing bioavailability by prolonging circulatory time in the bloodstream.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If CBD is incorporated in standard gummy formulations, then the gummy is easy to manufacture and consume, but the bioavailability is low due to rapid clearance from bloodstream
Solution Approach 1:
The patent employs a nested delivery system where CBD is first encapsulated within liposomal vesicles (inner layer), which are then coated with a polymer coating (outer layer). This multi-layer nested structure protects CBD from rapid clearance, extends circulatory time, and enhances bioavailability by allowing controlled release and avoidance of phagocyte attack.
Solution Approach 2:
The invention uses composite materials combining lipids (for liposomal vesicles) and polymers (for coating material such as polyethylene glycol or chitosan). This composite approach creates a delivery system that leverages the benefits of both liposomal encapsulation and polymer coating to achieve extended circulation and improved bioavailability.
2Duration of action of moving object
If a polymer coating is applied to liposomal vesicles, then circulatory time is prolonged, but the formulation complexity increases
Solution Approach 1:
The patent applies a thin polymer coating film (such as polyethylene glycol or chitosan) around the liposomal vesicles. This flexible thin film provides protection and extends circulatory time without significantly increasing formulation complexity, as the coating can be applied through established polymer coating techniques.
Solution Approach 2:
The polymer coating acts as an intermediary layer between the liposomal vesicles and the biological environment (bloodstream and phagocytes). This intermediary coating protects the CBD-containing liposomes from rapid clearance while maintaining a relatively simple formulation process through standard coating methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation significantly increases the bioavailability of CBD and other nutrients by maintaining them in the bloodstream for extended periods, providing sustained absorption and enhanced effectiveness.
Implementation Method 1
CBD incorporated in liposomal vesicles which may be physically coated and/or surrounded by a polymer
Implementation Method 2
coating material including, for example, a combination of polyethylene glycol and chitosan
Implementation Method 3
physically coated and/or surrounded by a polymer
Implementation Method 4
The coating material is free flowing in the dispersion such that the liposomal vesicles are surrounded by the coating material without being attached to the liposomal vesicles
Implementation Method 5
The dispersion may be filtered using a tangential flow technique, which washes out outer periphery of the liposomal vesicles so as to remove inactive ingredients contained outside the liposomal vesicles without washing out the coating material surrounding the liposomal vesicles
Data Source
AI summary
A gummy includes an inner portion, a formulation having a dispersion including a plurality of liposomal vesicles contained in the inner portion; and an outer portion which surrounds the inner portion. The formulation includes an active ingredient including cannabidiol (CBD), phospholipid contained in the liposomal vesicles, and a optionally added coating material, the CBD being incorporated within the liposomal vesicles. A method of making such gummy having the CBD formulation in the inner portion thereof includes setting up a central filling apparatus having a shell syrup hopper, a central filling hopper, and a manifold branch and nozzle mechanism; filling the shell syrup hopper with the base material; filling the central filling hopper with the CBD formulation; dispensing the base material and CBD formulation in the manifold branch and nozzle mechanism, and further into the gummy mold; and extracting the gummy from the gummy mold.