Liposome Encapsulation of Sphingomonas Olei Extract for Skin Absorption
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Solution Overview
Problem
The challenge is to enhance the transdermal absorption and skin regeneration efficacy of Sphingomonas olei culture extract, as it faces limitations in penetrating the human skin barrier when applied directly.
Innovation Solution
A liposome composition is developed, encapsulating the Sphingomonas olei culture extract with glycerin, hydrogenated lecithin, cetearyl olivate, and sorbitan olivate, to improve delivery and absorption into the skin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the culture extract of Sphingomonas olei is applied directly to the skin, then the skin regeneration efficacy is maintained, but the transdermal absorption is limited due to the physical protective barrier of the human skin
Solution Approach 1:
The patent uses liposomes as an intermediary carrier system to bridge the gap between the culture extract and the skin. The liposomes encapsulate the culture extract and facilitate its penetration through the skin barrier, acting as a mediator that enables both delivery and absorption without compromising the efficacy of the active ingredients.
Solution Approach 2:
The culture extract of Sphingomonas olei is nested inside the liposome structure. The liposome acts as a container that encapsulates the culture extract, allowing the active components to be protected and delivered systematically to the skin layers, thereby overcoming the physical barrier limitation.
2Quantity of substance
If the culture extract of Sphingomonas olei is encapsulated in liposomes, then the transdermal absorption is enhanced, but the formulation complexity increases
Solution Approach 1:
The patent optimizes specific parameters of the liposome formulation, including the ratio of phospholipids to cholesterol (1:0.5 to 1:2), the particle size (50-200 nm), and the composition of the culture extract (60-90% of total volume). By carefully controlling these parameters, the formulation achieves enhanced absorption while managing the complexity through standardized ratios and ranges.
3Object-affected harmful factors
If the phospholipid membrane of liposomes is used, then the skin-friendly safety is improved, but the manufacturing precision requirements increase
Solution Approach 1:
The patent specifies precise parameter ranges for the phospholipid composition, including the ratio of phospholipids to cholesterol (1:0.5 to 1:2) and the particle size (50-200 nm). These controlled parameters ensure the liposomes maintain skin-friendly properties while providing reproducible manufacturing results, balancing safety with manufacturing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The liposome composition significantly enhances skin regeneration and transdermal absorption of the Sphingomonas olei culture extract, demonstrating improved skin healing and penetration compared to non-encapsulated forms.
Implementation Method 1
The liposome composition according to the present disclosure encapsulates an extract of Sphingomonas olei culture broth in liposome, thereby efficiently delivering the culture extract of Sphingomonas olei into the skin
Implementation Method 2
exhibiting enhanced skin regeneration efficacy and improved transdermal absorption
Data Source
AI summary
The present disclosure relates to a liposome composition including a culture extract of Sphingomonas olei and a cosmetic composition including the same. The liposomal composition according to the present disclosure encapsulates an extract of Sphingomonas olei culture broth in liposome, thereby efficiently delivering the culture extract of Sphingomonas olei into the skin and thus exhibiting enhanced skin regeneration efficacy and improved transdermal absorption.