Liquid Chromatography Flow-Path Switching for Dual-Mode Sample Introduction
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Solution Overview
Problem
Conventional liquid chromatography systems are not suitable for both modes of analysis: one where the sample is diluted before introduction into the column and one where it is not, limiting their versatility.
Innovation Solution
A liquid chromatography system with a switchable flow path configuration that allows for either diluting or non-diluting sample introduction, using two pumps and mixers positioned differently based on the analysis mode, and controlled by a computer to adjust solvent ratios and paths accordingly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If the system is configured to dilute sample before introduction into column, then dilution mode analysis is enabled, but the system cannot perform non-dilution mode analysis
Solution Approach 1:
The flow path is segmented into multiple configurable routes using switch devices. The system divides the single flow path into at least two separate paths: one for dilution mode (where mobile phase is mixed before sample injection) and one for non-dilution mode (where sample is injected first then mixed with mobile phase). This segmentation allows the system to adapt to different analysis modes without requiring a completely different configuration for each mode.
Solution Approach 2:
The flow path configuration is made dynamic through the use of switch devices that can change the connectivity between components based on the selected analysis mode. The mixers and pumps can be dynamically repositioned or reconfigured via the switch device to create the appropriate flow path topology for either dilution or non-dilution analysis, allowing the system to adapt its structure in real-time.
2Adaptability or versatility
If additional pumps or mixers are added to enable both analysis modes, then mode versatility is improved, but system cost and complexity increase
Solution Approach 1:
The switch device serves multiple functions: it acts as a flow path router, a component positioner, and a mode selector simultaneously. The same physical components (pumps, mixers, injection port) are used in both dilution and non-dilution modes, but their relative positions and connectivity are changed by the switch device. This multi-functionality allows the system to achieve dual mode capability without adding redundant components.
Solution Approach 2:
The system pre-configures the flow path topology using the switch device before analysis begins. By establishing the appropriate flow path configuration in advance (either dilution-ready or non-dilution-ready), the system eliminates the need for mid-analysis reconfiguration or additional components to handle mode switching. The preliminary setup ensures optimal performance for the selected mode without requiring extra hardware.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables flexible analysis modes with improved performance and cost-effectiveness by allowing sample dilution or non-dilution without affecting standard mode performance, and reducing the need for additional pumps or mixers.
Implementation Method 1
a first mixer, a second mixer, and a switch device that switches a flow path from the first pump and the second pump to the column
Implementation Method 2
a switch device that switches a flow path from the first pump and the second pump to the column between a first flow path and a second flow path
Implementation Method 3
a column of a liquid chromatography analysis system
Data Source
AI summary
A first solution is supplied from a first pump. A second solution is supplied from a second pump. A flow path from the first pump and the second pump to a column is switched between a first flow path and a second flow path. In the first flow path, a first mixer is located upstream of an injection part for a sample, and the second mixer is located downstream of the injection part. In the second flow path, the first mixer and the second mixer are located upstream of the injection part. The first flow path is formed in a first mode in which the sample is diluted before introduction into the column. The second flow path is formed in a second mode in which the sample is not diluted before introduction into the column.