Liquid Delivery Device with Adsorptive Suction Filter
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Solution Overview
Problem
Conventional liquid delivery systems in liquid chromatography fail to effectively remove contaminants dissolved in the mobile phase without increasing the system's dead volume, which can lead to reduced analysis efficiency and sensitivity, especially in high-sensitivity analyses and gradient analyses.
Innovation Solution
A liquid delivery device equipped with a dissolved substance removal filter filled with adsorbing materials like activated carbon, silica gel, or modified polymers, positioned upstream of the liquid delivery pump to remove contaminants without increasing the system's internal volume, and optionally using multiple filters in series to handle various contaminants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a conventional suction filter is used to remove solid matter, then solid matter removal is achieved, but dissolved contaminants in the mobile phase cannot be removed
Solution Approach 1:
The patent employs a porous filler material within the suction filter that possesses adsorptive properties. This porous structure provides both mechanical filtration for solid particles and adsorption capacity for dissolved contaminants, resolving the limitation of conventional filters that only handle solid matter.
Solution Approach 2:
The invention uses a composite approach by combining the suction filter structure with adsorptive filler materials (such as activated carbon, silica gel, or polymer-based adsorbents). This composite configuration enables simultaneous removal of both solid particles and dissolved contaminants through a single integrated component.
2Reliability
If a dissolved substance removal means is added to the analysis system, then dissolved contaminants can be removed, but the dead volume increases and separation performance is lowered
Solution Approach 1:
The patent merges the dissolved substance removal function with the existing suction filter component. By integrating the adsorptive filler into the suction filter that is already part of the mobile phase delivery system, the invention eliminates the need for separate removal devices, thereby avoiding additional dead volume while achieving contaminant removal.
Solution Approach 2:
The suction filter is transformed into a multi-functional component that simultaneously performs mechanical filtration of solid particles and adsorption of dissolved contaminants. This universal approach allows a single component to handle multiple contamination types without requiring additional system elements that would increase dead volume.
3Reliability
If the internal volume in the system downstream of the liquid delivery pump is increased, then more contaminants can be removed, but the change in mobile phase composition during gradient analysis becomes slower and analysis efficiency is lowered
Solution Approach 1:
The patent implements contaminant removal at the suction side of the liquid delivery pump, which is upstream in the system. By performing the purification action before the mobile phase enters the pump and downstream system, contaminants are removed in advance, preventing them from adhering to pipes and columns. This preliminary action maintains fast gradient analysis efficiency while ensuring thorough contaminant removal.
Solution Approach 2:
The adsorptive filler in the suction filter acts as an intermediary that captures dissolved contaminants from the mobile phase before they can propagate through the system. This intermediary mechanism removes contaminants at the source without requiring increased system volume, thereby maintaining both purification effectiveness and gradient analysis performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively removes contaminants from the mobile phase, preventing system contamination and maintaining detection sensitivity, while avoiding increased dead volume, thus enhancing analysis efficiency and accuracy.
Implementation Method 1
The dissolved substance removal filter is filled with a filler having the property of adsorbing a dissolved substance in the mobile phase
Data Source
AI summary
A liquid delivery device includes a liquid delivery pump that sucks a mobile phase, which is liquid, from a mobile phase container containing the mobile phase through a suction pipe whose end is immersed in the mobile phase in the mobile phase container, and feeds the mobile phase, and at least one dissolved substance removal filter that is provided at a position upstream of the liquid delivery pump on a path through which the mobile phase flows and is filled with a filler having the property of adsorbing a dissolved substance in the mobile phase.