Liquid Embolic Composition With Transient Radiopacity and Drug Release

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Solution Overview

Problem

Existing liquid embolic systems lack the ability to provide transient and controlled delivery of therapeutic agents to the desired anatomical location in a controlled and sustained manner, and their radiopaque elements interfere with subsequent medical imaging and therapy planning.

Innovation Solution

A liquid embolic system that transitions from a liquid to a solid state upon contact with blood, incorporating a compound of interest for temporary radiopacity and controlled therapeutic release, using mechanisms like gelation, chemical binding, or encapsulation to ensure safe implantation and controlled release of therapeutic agents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Difficulty of detecting and measuring

If permanent radiopaque elements are incorporated into liquid embolic systems, then real-time fluoroscopic monitoring during embolization is enabled, but subsequent medical imaging and therapy planning are interfered with

Engineering Contradiction:

Improvereal-time fluoroscopic monitoringVSAvoidinterference with subsequent medical imaging

Core Design Contradiction:

Difficulty of detecting and measuringVSObject-affected harmful factors

Solution Approach 1:

The radiopaque element is designed to dynamically change its properties over time - initially providing strong radiopacity for real-time monitoring during embolization, then gradually degrading or dissipating to reduce interference with subsequent imaging. This time-dependent dynamic behavior allows the system to serve dual purposes: guiding the procedure and enabling post-procedure imaging.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The radiopaque element undergoes parameter changes in its radiopacity level over time. The concentration or visibility of the radiopaque element decreases gradually after embolization, transitioning from a state that provides excellent fluoroscopic contrast during delivery to a state that minimizes interference with subsequent diagnostic imaging and therapy planning.

Inventive Principle:

Principle #35Parameter changes

2Area of stationary object

If liquid embolic systems are used for distal vessel penetration, then treatment coverage is improved, but control over embolization location becomes more difficult

Engineering Contradiction:

Improvetreatment coverage areaVSAvoidcontrol over embolization location

Core Design Contradiction:

Area of stationary objectVSEase of operation

Solution Approach 1:

The system incorporates real-time feedback through fluoroscopic imaging that allows the operator to monitor the embolization process as it occurs. The radiopaque element provides continuous visual feedback about the embolic material's position and distribution, enabling the operator to adjust delivery parameters and control the embolization location even when treating distal vessels with wide treatment coverage.

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables safe implantation with real-time monitoring, reduces interference with diagnostic imaging, and allows for sustained therapeutic delivery to the target site, minimizing systemic toxicity and improving treatment efficacy.

Implementation Method 1

Liquid embolic systems that transition from a liquid to a solid state upon contact with blood

Methodology Applied

Scientific EffectGelation: Gel

Implementation Method 2

substantially solidify in situ at or near the target anatomy via a phase transition upon contact with blood, water, or other physiological liquids

Methodology Applied

Scientific EffectPhase transition: Phase Change

Data Source

PatentUS12599697B2Liquid embolic compositions with controlled release of radiopaque and therapeutic compounds and methods of using the same

Publication Date: 2026.04.14 BLACKSWAN VASCULAR INC

AI summary

The various embodiments of the subject invention included herein provide transiently radiopaque liquid embolic compositions and methods used to embolize blood vessels and/or provide controlled release of therapeutic agents when desired.