Liquid Phase Analysis Device Simplifying System Complexity

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Solution Overview

Problem

Existing liquid chromatography analyzers are complex and costly due to the need for multiple driving force supply units and switching valves to manage different eluents, leading to increased system complexity and high implementation costs.

Innovation Solution

A simplified liquid phase analysis device with a first fluid supply system for the sample, a second fluid supply system, an injection valve, and a chromatography column, where the injection valve switches flow paths to enable communication between the fluid supply systems and the chromatography column, reducing the number of components and complexity while using a single constant flow pump and injection valve.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If multiple driving force supply units and switching valves are used to manage different eluents, then the liquid chromatography analyzer can deliver various eluents and samples, but the system complexity increases and implementation costs increase

Engineering Contradiction:
Improveability to deliver various eluents and samplesVSAvoidsystem complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The single constant flow pump is designed to perform multiple functions: it can deliver different eluents (first eluent, second eluent) and samples through flow path switching, replacing the need for multiple dedicated driving force supply units. This multi-functional design maintains the ability to handle various fluids while significantly reducing system complexity

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges the functions of multiple driving force supply units into a single constant flow pump. By combining these functions and using flow path switching to route different fluids to the chromatography column, the system achieves the same operational capabilities with fewer components, thereby reducing both complexity and cost

Inventive Principle:
Principle #5Merging (Combining)

2Adaptability or versatility

If multiple driving force supply units and switching valves are used, then various eluents can be delivered, but the implementation costs increase

Engineering Contradiction:
Improveability to deliver various eluentsVSAvoidimplementation costs
Core Design Contradiction:
Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The single constant flow pump serves multiple purposes by delivering different eluents and samples through flow path control, eliminating the need for multiple expensive dedicated pumps. This universal component approach reduces implementation costs while maintaining the capability to deliver various eluents

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

By merging multiple driving functions into one pump system and using flow path switching to manage different fluid deliveries, the patent reduces the number of components that need to be manufactured and assembled, thereby lowering implementation costs

Inventive Principle:
Principle #5Merging (Combining)

3Adaptability or versatility

If the system uses multiple components for fluid delivery, then various eluents can be managed, but the fluid path length increases

Engineering Contradiction:
Improveability to manage different eluentsVSAvoidfluid path length
Core Design Contradiction:
Adaptability or versatilityVSLength of moving object

Solution Approach 1:

The patent consolidates fluid delivery through a single pump system with flow path switching, which shortens the overall fluid path compared to having multiple separate delivery systems. The merged architecture eliminates redundant piping and connections that would exist with multiple independent units

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration simplifies the system, reduces costs, shortens fluid paths, decreases analysis time, minimizes fluid loss, stabilizes baseline fluctuations, and enhances analysis accuracy.

Implementation Method 1

the chromatography column is used for separating components in the sample to be tested

Methodology Applied
Scientific EffectChromatography: Chromatography

Implementation Method 2

the injection valve is used for switching flow paths to enable the first fluid supply system and the second fluid supply system to communicate with a flow path of the chromatography column

Methodology Applied
Scientific EffectFluid flow switching:

Implementation Method 3

the second fluid supply system may include a constant flow pump for providing a driving force to drive the second fluid into the injection valve or the chromatography column

Methodology Applied
Scientific EffectPumping: Pump

Data Source

PatentUS11204338B2Liquid phase analysis device and analysis method for liquid phase analysis device
Publication Date: 2021.12.21 SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
  • US11204338B2 patent drawing
  • US11204338B2 patent drawing
  • US11204338B2 patent drawing

AI summary

A liquid phase analysis device includes a first fluid supply system for driving a first fluid or a sample to be detected, a second fluid supply system for driving a second fluid, an injection valve connected to the second fluid supply system and the first fluid supply system, a chromatographic column connected to the injection valve, and a detector connected to the chromatographic column, wherein the chromatographic column is used for isolating components in the sample to be detected; the detector is used for detecting the components, isolated by the chromatographic column, in the sample to be detected; the injection valve is used for switching a flow path so as to communicate flow paths of the first fluid supply system and second fluid supply system with a flow path of the chromatographic column. The liquid phase analysis device simplifies the complexity of a system, thereby reducing the costs of implementation.