Liquid Quantifying Device for Microfluidic Chip Accuracy
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Solution Overview
Problem
Existing microfluidic chips for in vitro diagnostics face challenges with low sensitivity and stability due to poor quantification accuracy of liquid volumes, especially for small quantities, and the complexity of integrating liquid quantification structures.
Innovation Solution
A liquid quantifying device with a preset volume and a liquid identification system using a light source and photoelectric sensor to ensure accurate liquid quantification, allowing for non-contact monitoring and control of liquid flow, reducing interference with the reaction system and simplifying chip production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If a containing bag with a specific volume is used for liquid quantification, then the quantifying structure is simple, but the quantification accuracy is poor due to liquid hanging on the bag surface and inconsistent deformation
Solution Approach 1:
The device is divided into a rigid chip body and a separate containing bag. The chip body provides precise microfluidic channels and structures, while the containing bag provides flexible volume adjustment. This segmentation allows each part to perform its optimal function without the limitations of integrating both functions into a single structure.
Solution Approach 2:
The containing bag acts as an intermediary between the liquid sample and the detection system. It provides a controlled environment for liquid storage and delivery, mediating the interaction between the flexible volume adjustment needed and the precise quantification required by the detection system.
2Device complexity
If a containing bag is used for liquid quantification, then the structure is simple, but the production difficulty increases when integrated into the chip
Solution Approach 1:
By separating the chip body and containing bag into distinct components, the invention simplifies manufacturing. The chip body can be produced using standard microfluidic fabrication techniques, while the containing bag can be separately manufactured and then integrated, avoiding the complexity of integrating a flexible bag directly into rigid chip structures.
3Adaptability or versatility
If conventional microfluidic chips are used, then integration is achieved, but sensitivity and stability are reduced due to poor quantification accuracy
Solution Approach 1:
The invention replaces the traditional mechanical containing bag system with a microfluidic-based liquid quantifying device that uses controlled fluid flow and pressure mechanisms. This substitution enables more precise volume control and consistent liquid delivery, improving detection stability while maintaining integration capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides high quantification accuracy and improved detection precision by ensuring consistent liquid volume measurement and simplifying the production process of microfluidic chips.
Implementation Method 1
the liquid identification device comprises a light source generating module and a photoelectric sensor; and the light source generating module, the liquid quantitative outlet and the photoelectric sensor are sequentially distributed in a vertical line
Data Source
AI summary
The invention discloses a liquid quantifying device which comprises a base body and a liquid quantifying area arranged on the base body; the liquid quantifying area is provided with a preset volume, two ends of the liquid quantifying area are respectively provided with a liquid quantitative inlet and a liquid quantitative outlet, the liquid flows into the liquid quantifying area from the liquid quantitative inlet and reaches the liquid quantitative outlet after the liquid quantifying area is filled; and a liquid identification device is arranged at a relevant position of the liquid quantitative outlet and used for identifying the liquid reaching the liquid quantitative outlet. The invention also discloses a use of the liquid quantifying device in a microfluidic chip. The invention can improve the accuracy of quantification and detection.