Lithium Root Canal Filling Composition for Intractable Infection Healing

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Conventional root canal filling materials, despite containing calcium hydroxide, are insufficient in promoting the healing of intractable pulpitis or apical periodontitis due to bacterial infections, and they face issues with lithium salt elution, solid-liquid separation, and operability.

Innovation Solution

A root canal filling material composition comprising a lithium salt, optionally with calcium hydroxide, water, and polyhydric alcohol, which promotes differentiation of dental pulp stem cells to osteoblasts, enhances immune response, and improves healing of periapical tissue, while maintaining operability and preventing solid-liquid separation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional root canal filling materials containing calcium hydroxide are used, then disinfectant activity and basic healing promotion are achieved, but the healing of intractable pulpitis or apical periodontitis is insufficient

Engineering Contradiction:

Improvehealing promotion activityVSAvoidhealing efficiency of intractable infections

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent combines calcium hydroxide with lithium salt in a composite filling material composition. This composite approach leverages the disinfectant properties of calcium hydroxide and the healing-promoting properties of lithium salt to achieve superior healing效果 for intractable infections compared to conventional single-component materials.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent optimizes the concentration ratio of lithium salt to calcium hydroxide within specific ranges (lithium salt: 0.0001-20%, calcium hydroxide: 2-70%) to achieve the optimal balance between disinfectant activity and healing promotion, thereby improving the healing efficiency of chronic infections.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If lithium salt is added to enhance healing activity, then healing of intractable pulpitis is improved, but solid-liquid separation and operability issues occur

Engineering Contradiction:

Improvehealing promotion activityVSAvoidoperability

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent carefully controls the concentration of lithium salt within 0.0001-20% and calcium hydroxide within 2-70% to optimize the balance between healing promotion and material operability, preventing solid-liquid separation while maintaining ease of operation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces water (1-100 times the weight of lithium salt) and polyhydric alcohol as intermediary substances that facilitate the dissolution and uniform distribution of lithium salt, preventing solid-liquid separation and maintaining the material's operability despite the presence of lithium salt.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If high concentration of lithium salt is used to improve healing, then healing activity is enhanced, but lithium salt elution becomes insufficient

Engineering Contradiction:

Improvehealing promotion activityVSAvoidlithium salt elution

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent optimizes the lithium salt concentration within 0.0001-20% and the water content within 1-100 times the weight of lithium salt to achieve the optimal balance between healing promotion activity and lithium salt elution, ensuring sufficient lithium release for healing while maintaining material stability.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively promotes the healing of intractable pulpitis and apical periodontitis by inducing osteoblast differentiation and enhancing immune response, with improved lithium salt elution and operability, ensuring effective sealing and tissue integration.

Implementation Method 1

promotes the differentiation from dental pulp stem cells to osteoblasts to activate or stimulate the bone metabolism in a periapical lesion

Methodology Applied

Scientific EffectCell differentiation:

Implementation Method 2

an aqueous solution of calcium hydroxide has a pH of 12.6, which is strong alkaline, and thus has a strong disinfectant activity

Methodology Applied

Scientific EffectAlkaline disinfection:

Implementation Method 3

activates or stimulates immune response

Methodology Applied

Scientific EffectImmune activation:

Implementation Method 4

further comprising water, wherein the water is contained 1 to 2 times the lithium salt in terms of weight ratio

Methodology Applied

Scientific EffectSolvation: Solvation

Data Source

PatentUS20250339349A1Dental root canal filling material composition

Publication Date: 2025.11.06 NIPPON SHIKA YAKUHIN

AI summary

A root canal filling material composition comprising a lithium salt has higher healing promoting activity than conventional root canal filling material compositions. Preferable compositions are (1) a composition further comprising a calcium hydroxide, (2) a combination composition of a paste A containing a higher fatty acid and rosin and a paste B containing magnesium oxide and a vegetable oil, and one or both of the paste A and the paste B comprise the lithium salt, and (3) a combination composition of a paste A and a paste B and hardens by mixing the paste A and the paste B, one or both of the paste A and the paste B comprise the lithium salt, one or both of the paste A and the paste B comprise a glass powder, the glass powder contains calcium oxide and silicon dioxide in amounts specified herein.