Live Cell Topical Formulation for Skin Regeneration
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Solution Overview
Problem
Current skin care treatments for maintaining skin tone, elasticity, and youthful appearance often take weeks to show results and can be irritating, with limitations for sensitive skin and side effects like sun sensitivity, peeling, and acne worsening.
Innovation Solution
The use of live cells obtained from a subject, grown in human platelet lysate or serum media to a confluency, for topical application to treat skin disorders and pain, including psoriasis, acne, and arthritis, with the cells being selected from skin cells, fibroblasts, mesenchymal stem cells, or primary human cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skin care treatments (Retin-A, hydroquinone, glycolic acid, beta hydroxyl acid) are used to improve skin tone and elasticity, then skin regeneration is promoted, but irritation, sun sensitivity, peeling, and acne worsening occur
Solution Approach 1:
The patent introduces live cells as an intermediary substance that mediates between the treatment goal (skin regeneration) and the skin surface. These live cells act as biological carriers that deliver regenerative effects without the direct chemical irritation caused by conventional treatments like Retin-A and hydroquinone. The cells serve as a bio-compatible bridge that promotes collagen production and skin renewal while avoiding harsh chemical interactions with sensitive skin.
Solution Approach 2:
The patent fundamentally changes the parameter of treatment composition from chemical compounds (acids, retinoids) to biological entities (live cells). This parameter change transforms the mechanism of action from direct chemical exfoliation and stimulation to biological regeneration through live cell activity. The live cells maintain viability through controlled culture conditions, creating a new therapeutic parameter space that avoids the irritation threshold of conventional treatments.
2Reliability
If conventional skin care treatments are applied to achieve improved skin appearance, then skin tone and elasticity improve over time, but the treatment duration is extended to weeks and irritation increases
Solution Approach 1:
The patent applies preliminary action by pre-culturing and activating live cells in controlled conditions before application to the skin. The cells are prepared in advance with optimal growth factors and nutrients, allowing them to be immediately effective upon contact with the skin. This pre-activation phase concentrates the regenerative potential, reducing the overall treatment duration compared to conventional treatments that rely on gradual chemical penetration and activation over weeks.
Solution Approach 2:
The patent maintains continuity of useful action through the sustained activity of live cells that continue to function and regenerate after application. Unlike conventional treatments that require repeated applications over weeks to accumulate effect, the live cells provide continuous regenerative activity as they migrate and function within the skin tissue, extending the therapeutic action beyond the initial application period.
3Reliability
If conventional skin care treatments are used to treat skin disorders, then some therapeutic effect is achieved, but the treatments are not suitable for sensitive skin and can worsen acne
Solution Approach 1:
The patent employs self-service by using the patient's own live cells (autologous cells) that are harvested, cultured, and re-administered to the same patient. These autologous cells are inherently compatible with the patient's skin, eliminating allergic reactions and sensitivity issues associated with foreign substances. The cells self-regulate their activity based on the local skin environment, providing adaptive therapy that is safe for sensitive skin and acne-prone areas without the harsh effects of conventional treatments.
Data Source
AI summary
Disclosed herein is a method of preparing a subject's cells for topical treatment of a subject in need. Also provided is a topical formulation and methods of treating a subject suffering a skin disorder and pain using the topical formulation. Also disclosed herein are devices and systems for micronizing an aspirate in preparation of such a topical formulation.