Wound Therapy Combining LLLT and Nitric Oxide Donor
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Solution Overview
Problem
Current wound treatment methods lack effective solutions for rapid and efficient healing, particularly for chemical, thermal, and traumatic wounds, as they often face complications such as bacterial infection and delayed healing processes.
Innovation Solution
The combination of low-level light therapy (LLLT) and a nitric oxide donor, specifically nitrosyl-cobinamide (NO-Cbi), administered through a light source and a suitable carrier like a time-release hydrogel or aerosol spray, to enhance wound healing by activating the electron transport chain and cGMP/Erk signaling pathways.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional wound treatment methods are used, then treatment is provided for various wounds, but healing is delayed and bacterial infection risk increases
Solution Approach 1:
The patent combines low-level light therapy (LLLT) with nitric oxide donor (NO-donor) chemical compounds into a single wound treatment protocol. The light source activates the NO-donor compound locally at the wound site, creating a synergistic effect that accelerates healing and reduces infection risk more effectively than either treatment alone.
Solution Approach 2:
The patent utilizes specific wavelengths of light (typically in the red to near-infrared range) to activate the NO-donor compound. By controlling light parameters (wavelength, intensity, duration) and NO-donor concentration, the treatment optimizes cellular responses including reduced oxidative stress, enhanced ATP production, and stimulated tissue regeneration, thereby accelerating wound closure.
2Productivity
If LLLT and NO-donor combination therapy is applied, then wound healing is accelerated, but treatment complexity increases
Solution Approach 1:
The treatment system is divided into separable components: a light source device and a NO-donor compound application system. This segmentation allows flexibility in administration— the light can be applied separately or in combination with topical NO-donor application, enabling clinicians to adjust treatment intensity and complexity based on wound severity while maintaining therapeutic effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This combination significantly accelerates wound healing by reducing reactive oxygen species, increasing ATP production, and promoting cell migration, resulting in more rapid closure than either treatment alone, with LLLT validated as acting through the electron transport chain-C-ox pathway and NO-Cbi through cGMP/Erk signaling.
Implementation Method 1
providing low level light therapy (LLLT)... The light source of the LLLT is a laser or a LED... LLLT validated as acting through the electron transport chain-C-ox pathway
Implementation Method 2
the chemical compound is a nitric oxide donor... Examples of the nitric oxide donor include but are not limited to nitrosyl-cobinamide (NO-Cbi)... NO-Cbi through cGMP/Erk signaling
Data Source
AI summary
The invention generally relates to methods for treating and/or reducing the severity of a wound in a subject. Provided are wound therapies combining low level light therapy (LLLT) and a nitric oxide (NO) donor to treat and/or reduce the severity of the wound. The LLLT and NO donor may be administered concurrently or sequentially. Also provided are wound treatment systems and kits including a light source and a NO donor, which are administered to a wounded subject. Further provided are pharmaceutical compositions that comprise a NO donor and are formulated to be administered in conjunction with LLLT.