Lossy Mode Resonance Biosensor Electrical Polarity Control
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Solution Overview
Problem
Current biosensors, particularly those using surface plasmon resonance (SPR) technology, face challenges in controlling electrical polarity, leading to low sampling rates and inefficient detection of polar molecules, which limits their detection efficiency and quality.
Innovation Solution
An electrical polarity adjustable biosensor based on lossy mode resonance (LMR) is developed, comprising a first polarity module with an optical waveguide layer, a lossy mode resonance layer, and a bioprobe layer, along with a second polarity module and spacers, allowing for the formation of an electric field that enhances the sampling rate of polar molecules by adjusting electrical polarity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If surface plasmon resonance (SPR) technology is used for biosensing, then high sensitivity is achieved, but the sampling rate of polar molecules is low due to inability to control electrical polarity
Solution Approach 1:
The patent applies dynamics by making the electrical polarity controllable and adjustable through external voltage application. The sensing system transitions from a static polarity state to a dynamic one where the polarity can be changed in real-time to optimize the sampling of different polar molecules, thereby resolving the contradiction between maintaining high sensitivity and improving sampling rate.
Solution Approach 2:
The patent changes the electrical polarity parameter of the sensing system by applying external voltages to create an electric field. This parameter change allows the system to selectively enhance the sampling rate of polar molecules with different polarities while maintaining the high sensitivity characteristic of SPR technology.
2Reliability
If SPR technology with precious metal materials is used, then good sensing effect is achieved, but the cost is high and the material is easily oxidized
Solution Approach 1:
The patent replaces expensive precious metals with alternative materials that are cheaper and more stable. While the alternative materials may have shorter operational lifetimes in isolation, the overall system design with controllable electrical polarity compensates for this, providing a cost-effective and reliable sensing solution.
Solution Approach 2:
The patent likely employs composite material structures that combine different materials to achieve both good sensing performance and cost-effectiveness. The composite structure may include alternative metals or metal oxides combined with protective or functional layers that prevent oxidation while maintaining sensing capability.
3Measurement precision
If prime-type sensor architecture is used, then high sensitivity is achieved, but the device volume is large and requires expensive optical equipment
Solution Approach 1:
The patent replaces complex mechanical optical systems with a more compact design that utilizes controllable electrical fields. By substituting the need for large-scale mechanical optical equipment with an electrically controlled sensing mechanism, the device volume is reduced while maintaining high sensitivity through the interaction of the electric field with polar molecules.
Solution Approach 2:
The patent transitions from a traditional optical-dimensional approach to incorporating an electrical dimension for control. By adding the dimension of electrical polarity control, the system achieves high sensitivity without requiring large mechanical optical components, thereby reducing device volume and complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor achieves improved detection efficiency and quality by enabling controlled electrical polarity, suitable for miniaturization and low-cost production, with the ability to detect polar molecules effectively, such as glycated hemoglobin (HbA1c), and offers advantages over SPR by allowing both TE and TM wave resonance.
Implementation Method 1
electrical polarity adjustable biosensor based on lossy mode resonance
Implementation Method 2
An electric field is formed between the lossy mode resonance layer and the second electrode layer, the electric field acts on at least one of the pluralities of bioprobes and the object to be tested
Implementation Method 3
an optical waveguide layer, a lossy mode resonance layer and a bioprobe layer stacked on each other, the lossy mode resonance layer is disposed on one side of the optical waveguide layer, and two opposite sides of the optical waveguide layer being a light input end and a light output end
Implementation Method 4
the plurality of bioprobes are formed by performing a surface modification on the lossy mode resonance layer, and the biomaterial sensing region is for injecting an object to be tested
Data Source
AI summary
An electrical polarity adjustable biosensor based on lossy mode resonance includes a first polarity module, a second polarity module, and a plurality of spacers disposed between the first polarity module and the second polarity module. A biomaterial sensing region for injecting an object to be tested is formed between a bioprobe layer of the first polarity module and a second electrode layer of the second polarity module. An electric field is formed between a lossy mode resonance layer of the first polarity module and the second electrode layer, and the electric field acts on a plurality of bioprobes of the bioprobe layer and the object to be tested. The present disclosure further includes a method of using the electrical polarity adjustable biosensor based on lossy mode resonance.