Loaded Vegetable Oleosomes for Stable sn2 C16 Triglyceride Delivery
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Solution Overview
Problem
Existing colloidal systems lack an effective matrix for delivering triglycerides with saturated C16 fatty acids positioned at the sn2 position, providing inadequate oxidative stability and gastric phase stability, necessitating a carrier that allows tailoring of the fatty acid profile for nutritional compositions.
Innovation Solution
A composition of loaded isolated vegetable oleosomes with triglycerides having saturated C16 fatty acids at the sn2 position, where at least 80 wt.% of the total lipids are present inside the oleosomes, prepared by blending triglycerides with isolated vegetable oleosomes and subjecting the mixture to high-shear force.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing colloidal systems are used as matrices for delivering triglycerides, then the delivery function is provided, but oxidative stability and gastric phase stability are insufficient
Solution Approach 1:
The invention changes the structural parameters of the colloidal system by specifying triglycerides with saturated C16 fatty acids positioned at the sn2 position, achieving both improved oxidative stability and gastric phase stability while maintaining the ability to tailor fatty acid profiles for different nutritional needs
Solution Approach 2:
The invention creates a composite oleosome system combining phospholipid membranes with specifically structured triglycerides (sn2-positioned saturated C16 fatty acids), forming a stable matrix that provides both protective and deliverable functions for lipophilic bioactive compounds
2Reliability
If isolated oleosomes are loaded with triglycerides having saturated C16 fatty acids at sn2 position, then oxidative stability and gastric phase stability are improved, but the complexity of preparing triglycerides with specific fatty acid positioning increases
Solution Approach 1:
The invention applies local quality by positioning saturated C16 fatty acids specifically at the sn2 position of triglycerides, creating a localized structural feature that provides enhanced stability while the rest of the triglyceride structure can be varied to meet different nutritional requirements
3Object-affected harmful factors
If a carrier system is designed to provide oxidative stability, then protection against oxidation is achieved, but the ability to tailor fatty acid profile for specific nutritional needs is limited
Solution Approach 1:
The oleosome carrier system performs multiple functions simultaneously: it provides oxidative stability through its phospholipid membrane structure, ensures gastric phase stability through sn2-positioned triglycerides, and enables fatty acid profile customization by varying the triglyceride composition while maintaining the core protective structure
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The oleosome composition enhances oxidative stability and gastric phase stability of triglycerides, serving as a carrier for improved delivery and stability of lipophilic bioactive compounds.
Implementation Method 1
subjecting the blend obtained from step a) to a high-shear force and obtaining an oleosome composition comprising loaded isolated vegetable oleosomes
Data Source
AI summary
Present invention relates to an oleosome composition comprising loaded isolated vegetable oleosomes being isolated vegetable oleosomes loaded with one or more sources of triglycerides having saturated C16 fatty acids that are positioned at the sn2 position, which are present in the inside of the loaded oleosomes and wherein at least 80 wt. % of total weight of lipids in composition is present in the oleosomes. It further relates to the use of isolated vegetable oleosomes as a carrier for these triglycerides. Present invention moreover relates to a product comprising the oleosome composition, wherein product is selected from the group consisting of food products, feed products, pharmaceutical products, personal care products, nutritional compositions, and industrial products. Present invention further relates to a process for loading isolated vegetable oleosomes.