Low-Crystallinity Cellulose for Fermentable Dietary Fiber

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Solution Overview

Problem

Cellulose is difficult to degrade in the human gut due to its high crystallinity, limiting its fermentability and physiological health benefits, and existing dietary fiber additives often cause discomforts, especially for individuals with inflammatory bowel disease.

Innovation Solution

A food-grade modification strategy involving mechanical impact and chemical hydrolysis with organic acids to decrease the crystallinity of cellulose, followed by a mechanical post-treatment, enhancing its accessibility and fermentability in the colon.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If cellulose is used as dietary fiber, then it provides bulk and structure, but it is not fermented in the large intestine due to high crystallinity

Engineering Contradiction:
ImprovefermentabilityVSAvoidcrystallinity
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies parameter changes by modifying the crystallinity and degree of polymerization of cellulose through chemical hydrolysis and mechanical treatment. This transforms native high-crystallinity cellulose into low-crystallinity derivatives that are fermentable in the colon, directly resolving the contradiction between maintaining structural integrity and enabling fermentation.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention creates composite material structures by combining cellulose with other dietary fiber components during processing. This composite approach allows the cellulose to maintain its bulk-providing function while acquiring new fermentable characteristics through the integrated material structure.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If existing fiber additives like wheat bran are used, then they provide dietary fiber, but they have organoleptic and techno-functional shortcomings

Engineering Contradiction:
Improvedietary fiber contentVSAvoidorganoleptic properties
Core Design Contradiction:
Quantity of substanceVSEase of operation

Solution Approach 1:

The patent uses cellulose, an abundant and inexpensive material, as a disposable dietary fiber source that can be processed into value-added fermentable products. This replaces expensive or problematic fiber additives while maintaining or improving functional properties.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Reliability

If inulin or inulin-derived oligosaccharides are introduced, then they provide fermentable fiber, but they are fermented too fast causing flatulencies and diarrhoea

Engineering Contradiction:
ImprovefermentabilityVSAvoidgastrointestinal discomfort
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent controls the degree of polymerization and crystallinity parameters of cellulose to achieve moderate fermentability. This intermediate level of fermentability provides health benefits without the excessive fermentation effects that cause gastrointestinal discomfort, distinguishing it from rapidly fermented inulin.

Inventive Principle:
Principle #35Parameter changes

4Reliability

If mechanical impact and chemical hydrolysis are applied to decrease crystallinity, then fermentability is enhanced, but the complexity of the processing increases

Engineering Contradiction:
ImprovefermentabilityVSAvoidprocessing complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges mechanical impact treatment with chemical hydrolysis in an integrated processing sequence. This combination approach achieves effective crystallinity reduction and fermentability enhancement while managing processing complexity through coordinated application of multiple treatment methods.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent applies preliminary mechanical impact treatment to cellulose before chemical hydrolysis. This preliminary action disrupts the crystalline structure and increases accessibility to chemical reagents, making the subsequent hydrolysis more efficient and reducing overall processing complexity.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The modified cellulose fibers exhibit increased fermentability, with enhanced production of short-chain fatty acids, reduced pH, and improved health benefits, while maintaining insoluble characteristics, thus addressing the recalcitrance and discomfort issues associated with prior art cellulose.

Implementation Method 1

A food-grade modification strategy involving mechanical impact and chemical hydrolysis with organic acids to decrease the crystallinity of cellulose

Methodology Applied
Scientific EffectMechanical impact: Impact Force

Implementation Method 2

chemical hydrolysis with organic acids to decrease the crystallinity of cellulose

Methodology Applied
Scientific EffectChemical hydrolysis: Hydrolysis

Implementation Method 3

fermentation of dietary fibres like cellulose in the colon is correlated with different positive health effects, linked to the production of short-chain fatty acids (SCFA)

Methodology Applied
Scientific EffectFermentation: Fermentation

Data Source

PatentUS20240408127A1Short amorphous cellulose polymers
Publication Date: 2024.12.12 KATHOLIEKE UNIV LEUVEN
  • US20240408127A1 patent drawing
  • US20240408127A1 patent drawing
  • US20240408127A1 patent drawing

AI summary

The invention relates to the use of a cellulose with an average degree of Polymerization (DP) below 100 and a crystallinity index below 0.5 as a fermentable dietary fiber in a food composition.