Low-Dose X-Ray Preview via Correlated Noise Injection

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Solution Overview

Problem

Current methods for selecting low-dose protocols in cone-beam CT scans, especially for flat-panel detectors, fail to accurately account for correlated noise, leading to suboptimal image quality and increased radiation dose in image-guided surgery and radiation therapy applications.

Innovation Solution

A method that involves performing an initial scan, creating an initial image projection, injecting correlated noise into the projection, reconstructing the image using a specific algorithm, and displaying a low-dose preview image to enable selection of optimal x-ray exposure levels for subsequent scans, directly addressing the challenges of correlated noise in flat-panel detectors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If simulated dose reduction methods assume spatially uncorrelated noise, then the methods can be applied to multi-detector CT scanners, but the methods fail to accurately reproduce image noise characteristics for flat-panel detectors used in CBCT

Engineering Contradiction:
Improveapplicability of dose reduction methodVSAvoidaccuracy of noise reproduction
Core Design Contradiction:
Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent applies local quality by distinguishing between different detector types and applying appropriate noise models to each. For flat-panel detectors, correlated noise models are used specifically at the detector level, while uncorrelated noise assumptions can be used for multi-detector CT scanners. This localized adaptation allows each detector type to have its specific noise characteristics accurately reproduced without compromising the versatility of the overall dose reduction simulation framework.

Inventive Principle:
Principle #3Local quality

2Object-affected harmful factors

If lower dose techniques are used to reduce radiation exposure, then patient radiation dose is reduced, but image noise increases

Engineering Contradiction:
Improveradiation dose to patientVSAvoidimage quality
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent applies preliminary action by performing low-dose simulation before the actual CBCT scan. The simulation uses correlated noise models to predict the image quality that would result from various dose levels, allowing clinicians to select the minimum adequate dose in advance. This preliminary assessment prevents both over-dosing (excessive radiation) and under-dosing (unacceptable image quality) by providing accurate noise predictions at different dose levels before the actual scan occurs.

Inventive Principle:
Principle #10Preliminary action

3Reliability

If repeat CBCT scans are acquired for image-guided surgery and radiation therapy, then imaging tasks can be performed, but total accumulated radiation dose increases

Engineering Contradiction:
Improvecompletion of imaging tasksVSAvoidtotal accumulated radiation dose
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by enabling dynamic adjustment of dose levels for each repeat CBCT scan based on the specific imaging task requirements. The correlated noise simulation allows clinicians to evaluate different dose parameters for different imaging tasks (e.g., setup vs. verification scans) and select the minimum adequate dose for each. This parameter optimization across multiple scans significantly reduces the total accumulated radiation dose while ensuring each scan meets its specific imaging task requirements.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for accurate depiction of image quality at reduced doses, preserving spatial resolution and contrast, and enabling patient-specific, task-oriented selection of minimum-dose protocols, thereby reducing radiation exposure while maintaining image quality.

Implementation Method 1

performing, by at least one processor, an initial scan of a patient at a pre-selected amount of x-ray exposure with an x-ray imaging device

Methodology Applied
Scientific EffectX-ray: X-Ray

Data Source

PatentUS10064591B2System, method and computer readable medium for preview of low-dose x-ray projection and tomographic images
Publication Date: 2018.09.04 JOHNS HOPKINS UNIVERSITY
  • US10064591B2 patent drawing
  • US10064591B2 patent drawing
  • US10064591B2 patent drawing

AI summary

A novel method for simulating radiation dose reduction that enables previews of low-dose x-ray projection images, low-dose computed tomography images and/or cone-beam CT images. Given an existing projection or set of projections of the patient acquired at a nominal dose, the method provides a means to produce highly accurate preview images that accurately reflect the image quality associated with reduced radiation dose. The low-dose preview image accounts for characteristics of the imaging system, including blur, variations in detector gain and electronic noise, and does so in a manner that yields accurate depiction of the magnitude and correlation of image noise in the preview images. A calibration step may be included to establish the system-specific relationship between the mean and variance in detector signal, and incorporate an accurate model for system blur such that correlations in the resulting LDP images are accurate.