Low-Glycemic Carbohydrate Composition for Flat Glucose Response
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Solution Overview
Problem
Current nutritional products fail to provide sustained glucose release without causing high blood glucose concentrations, particularly in individuals with insulin resistance, leading to severe health issues such as cardiovascular problems, kidney issues, and neuropathies.
Innovation Solution
A low-glycemic carbohydrate composition combining monosaccharides like galactose and mannose with glucose-containing oligosaccharides having non-α-1,4 bonds, which stimulates insulin release while maintaining stable glucose levels, characterized by a glycemic index below 60, providing rapid but sustained energy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If starch or other dietetic available sources of glucose are consumed, then glucose is rapidly released and absorbed, providing quick energy, but glucose concentrations in blood increase rapidly causing high postprandial glucose response
Solution Approach 1:
The patent changes the chemical structure parameters of carbohydrates by using oligosaccharides with non-α-1,4 bonds (such as α-1,6 bonds in isomaltulose) instead of standard starch structures. This structural modification alters the digestion and absorption rate, providing sustained glucose release without rapid blood glucose spikes, thus resolving the contradiction between quick energy provision and high postprandial glucose response.
Solution Approach 2:
The patent creates a composite carbohydrate composition combining monosaccharides (galactose, mannose) with glucose-containing oligosaccharides. This composite structure provides both rapid absorption (from monosaccharides) and sustained release (from oligosaccharides), while the specific bond structures prevent rapid glucose release, thereby maintaining stable blood glucose levels without sacrificing energy availability.
2Object-affected harmful factors
If dietetic fibre like gums or pectin is included to induce low postprandial glucose response, then glucose release is slowed, but viscosity increases causing bloating, flatulence, loss of appetite and possibly constipation
Solution Approach 1:
The patent changes the molecular structure parameters by using oligosaccharides with non-α-1,4 bonds (specifically α-1,6 bonds) which are not substrates for amylase enzymes. This structural parameter change allows the carbohydrates to resist rapid digestion and absorption, achieving low postprandial glucose response without forming viscous gels like traditional fibres, thus avoiding digestive discomfort while maintaining glucose control.
3Use of energy by moving object
If glucose is released rapidly to provide quick energy, then energy availability increases, but blood glucose levels spike causing metabolic stress and insulin resistance
Solution Approach 1:
The patent implements periodic glucose release through the use of oligosaccharides with non-α-1,4 bonds. These structures provide an initial rapid phase from monosaccharide components followed by a sustained release phase from oligosaccharide digestion, creating a periodic rather than continuous glucose supply. This periodic action maintains energy availability while preventing sustained high blood glucose levels and associated metabolic stress.
Data Source
AI summary
A low-glycemic available carbohydrate composition of the invention contains the following components:(i) 5-60 wt. % of one or more monosaccharides selected from monosaccharides other than glucose and fructose, in particular galactose, ribose and mannose;(ii) 15-95 wt. % of oligosaccharides having a length of 2 to 20 anhydromonose units, at least half of which are anhydroglucose units linked by non-α-1,4 bonds; these oligosaccharides preferably comprising disaccharides such as palatinose, isomaltose and trehalose and/or non-α-1,4 linked higher glucose-containing oligosaccharides;(iii) 0-45 wt. % of other available carbohydrates, such as glucose and maltodextrins.This carbohydrate composition can be part of a food composition for the treatment of diabetes, obesitas, insulin resistance, or for postprandial glucose response.