Low-Mass Antigen SAW Sensor With Antigen-BSA Layer for Rapid Detection
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Solution Overview
Problem
Existing surface acoustic wave (SAW) biosensors face challenges in efficiently detecting low mass antigens due to limitations in sensitivity and speed, particularly in the detection of various types of antigens.
Innovation Solution
A low mass antigen detecting device is designed with a piezo-electric substrate, a sensing layer containing antigen-BSA, and IDT electrodes, which utilizes antigen-antibody binding to detect antigens by analyzing changes in output frequency, and is housed in a cartridge with a cover and connection part for easy integration with external devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional SAW biosensors use gold-deposited sensing layers with functionalized receptor biomaterials, then the sensors can detect target materials through frequency changes, but the sensitivity and detection speed for low mass antigens are insufficient
Solution Approach 1:
The patent changes the material parameter of the sensing layer from conventional gold deposition to a specialized coating that enhances interaction with low mass antigens. This parameter change in the sensing layer material enables both higher sensitivity for detecting low mass antigens and maintains fast detection speed, resolving the contradiction between measurement precision and productivity
2Measurement precision
If the sensing layer uses antigen-BSA complexes for specific antigen detection, then the device achieves high sensitivity, but the device structure becomes more complex requiring cartridge integration
Solution Approach 1:
The patent implements a cartridge structure that houses the sensor with antigen-BSA sensing layer. The cartridge acts as a nested container that integrates the complex sensing components, providing a compact and self-contained unit that achieves high sensitivity while managing device complexity through hierarchical integration
3Adaptability or versatility
If the sensor uses multiple antigen-BSA types for detecting various antigens, then the versatility of detection increases, but the manufacturing process becomes more difficult
Solution Approach 1:
The patent employs a universal sensing layer design using antigen-BSA complexes that can detect multiple types of antigens. This multi-functional sensing layer is integrated into the SAW sensor, allowing a single device structure to perform versatile antigen detection while maintaining ease of manufacture through standardized fabrication processes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables rapid and accurate detection of various antigens with high sensitivity and reliability, allowing for on-site testing of drug ingredients by analyzing continuous or discontinuous output frequencies.
Implementation Method 1
Electrical energy of an input radio frequency (RF) is converted into sound energy having surface acoustic waves at an input inter digital transducer (IDT)
Implementation Method 2
Surface acoustic wave (SAW) sensors are being widely used to measure changes in environmental factors such as temperature sensors, gas sensors, and biosensors
Data Source
AI summary
Provided is a low mass antigen detecting device for quickly and conveniently detecting various types of antigens. In a low mass antigen detecting device for detecting a low mass antigen through a sensor, the sensor includes a piezo-electric substrate, a sensing layer coupled to one surface of the piezo electric substrate and comprising at least one antigen-BSA, an input IDT electrode disposed at one side of the piezo-electric substrate to apply an input frequency provided as a sweep frequency, and an output IDT electrode disposed at the other side of the piezo-electric substrate to output an output frequency.