Low-Molecular-Weight Cosmetic Composition for Skin Regeneration
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Solution Overview
Problem
Current cosmetic products mimicking the extracellular matrix often use animal-derived components, which pose safety concerns and have limited skin penetration due to high molecular weights, hindering effective skin regeneration and anti-aging benefits.
Innovation Solution
A cosmetic composition comprising a tripeptide (Gly-Pro-Hyp), low-molecular-weight hyaluronic acid, and vitamins, all of plant origin or synthetic, formulated to mimic the extracellular matrix, allowing for easy skin penetration and stimulating skin cell regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If animal-derived ECM components are used in cosmetic products, then the composition can mimic the extracellular matrix structure, but safety problems such as pathogen infection occur and skin penetration is limited due to high molecular weight
Solution Approach 1:
The patent segments the high molecular weight ECM components into low molecular weight derivatives. Specifically, collagen is converted to collagen peptides with molecular weights of 1-10 kDa, and hyaluronic acid is converted to low molecular weight hyaluronic acid with molecular weights of 10-100 kDa. This segmentation maintains the beneficial biological activities while eliminating pathogen risks and improving skin penetration.
Solution Approach 2:
The patent changes the molecular weight parameter of ECM components from high (300,000 Da for collagen, several hundred thousands to millions for hyaluronic acid) to low (1-100 kDa range). This parameter change resolves the contradiction by enabling better skin penetration and safety while preserving the ECM-mimicking functionality.
2Stability of the object's composition
If high molecular weight collagen and hyaluronic acid are used to mimic ECM, then the structural integrity and viscosity are maintained, but skin penetration and absorption are limited
Solution Approach 1:
The patent divides the large ECM molecules into smaller peptide and oligosaccharide units. Collagen is segmented into tripeptides and small peptides, while hyaluronic acid is segmented into low molecular weight oligosaccharides. This segmentation enables faster skin penetration while the cumulative effect of multiple small units maintains the desired structural and functional properties.
Solution Approach 2:
The patent systematically changes the molecular weight parameter from the high range (300,000 Da to several millions) to the low range (1-100 kDa). This parameter change directly addresses the penetration speed issue while the patent formulations maintain appropriate concentrations and combinations to preserve structural integrity effects.
3Reliability
If animal-derived collagen and hyaluronic acid are used, then the ECM-mimicking effect is achieved, but safety concerns and limited penetration persist
Solution Approach 1:
The patent segments ECM components into low molecular weight derivatives that are inherently safer and more penetrable. Collagen becomes collagen peptides (1-10 kDa), hyaluronic acid becomes low molecular weight hyaluronic acid (10-100 kDa), and these segmented forms eliminate pathogen risks while improving absorption.
Solution Approach 2:
The patent changes the molecular weight parameter to resolve the dual problem of safety and penetration. The low molecular weight range (1-100 kDa) provides both safety by eliminating animal pathogen risks and improved penetration kinetics, simultaneously addressing both worsening factors.
Data Source
AI summary
The present invention relates to a cosmetic composition which mimics the extracellular matrix to stimulate the regeneration of skin cells, and more particularly to a cosmetic composition which contains active ingredients consisting of low-molecular-weight materials, which easily permeate through the skin, at a composition ratio similar to that in the extracellular matrix. The cosmetic composition stimulates the repair of the skin to maintain homeostasis and is effective for the regeneration of skin cells.