Low pH Niacinamide and Ribose Composition for Skin Barrier

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Solution Overview

Problem

Existing skin care compositions formulated at higher pH levels, typically above 4.0, reduce the bioavailability of niacinamide due to complex formation, limiting their ability to improve skin barrier function and appearance benefits, while lower pH compositions are challenging to stabilize effectively.

Innovation Solution

A low pH skin care composition comprising niacinamide and ribose, formulated between 1.0 and 4.0, which enhances skin barrier function, reduces hyperpigmented spots, and improves skin tone by increasing bioavailability and providing exfoliation benefits.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If skin care compositions are formulated at higher pH levels (above 4.0), then ingredient stability is improved, but niacinamide bioavailability decreases due to complex formation

Engineering Contradiction:

Improveingredient stabilityVSAvoidniacinamide bioavailability

Core Design Contradiction:

Stability of the object's compositionVSQuantity of substance

Solution Approach 1:

The patent changes the pH parameter from conventional higher levels (above 4.0) to low pH levels (1.0-4.0), which fundamentally alters the chemical environment to prevent niacinamide complex formation while maintaining ingredient stability through the synergistic combination with ribose and appropriate buffer systems

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If skin care compositions are formulated at lower pH levels (1.0-4.0), then niacinamide bioavailability and skin barrier function are improved, but composition stability becomes challenging

Engineering Contradiction:

Improveniacinamide bioavailabilityVSAvoidcomposition stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent creates a composite formulation combining niacinamide with ribose and other stabilizing ingredients that work synergistically to maintain composition stability at low pH, where the ribose and buffer system prevent degradation while allowing niacinamide to remain bioavailable

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent introduces ribose and buffer systems as intermediary substances that mediate between the low pH environment and niacinamide stability, preventing direct harmful interactions while maintaining the beneficial low pH effects on skin barrier function

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If conventional pH formulations are used, then ingredient stability is maintained, but skin barrier function and appearance benefits are limited

Engineering Contradiction:

Improveingredient stabilityVSAvoidskin barrier function improvement

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent changes the pH parameter to low levels (1.0-4.0) which directly enhances skin barrier function and appearance benefits while using ribose and stabilizing ingredients to maintain composition stability, thereby resolving the contradiction between stability and efficacy

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentEP3236928B1Method of treating a skin condition and compositions therefor

Publication Date: 2020.12.09 PROCTER & GAMBLE CO

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AI summary

Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.