Low Profile Prosthetic Mitral Valve with Flared Atrial End
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Solution Overview
Problem
Current treatments for mitral regurgitation, including traditional surgical repair and less invasive transcatheter methods, face challenges such as the need for open heart surgery, long recovery periods, and difficulties in implanting and regulatory approval for commercial distribution of prosthetic valves, which are often large and difficult to accurately anchor.
Innovation Solution
Development of a low-profile, expandable prosthetic mitral valve with a radially expandable frame formed from interconnected struts, featuring ventricular anchors and commissure tabs for secure anchoring, and a delivery system that allows for minimally invasive deployment and release from a catheter, reducing tissue trauma and perivalvular leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional surgical repair is used to treat mitral regurgitation, then effective valve repair is achieved, but open heart surgery is required with long recovery periods
Solution Approach 1:
The patent replaces traditional open-heart surgical mechanical repair with a transcatheter delivery system that deploys a self-expanding prosthetic valve through a catheter, eliminating the need for sternotomy and cardiopulmonary bypass while maintaining effective valve replacement
Solution Approach 2:
The prosthetic valve is nested within a delivery catheter in a compressed state, allowing it to be delivered through a peripheral vessel and then self-expand at the target site, reducing procedural invasiveness and recovery time compared to traditional open surgery
2Reliability
If existing prosthetic valves are used, then valve replacement is achieved, but they are large and difficult to accurately anchor
Solution Approach 1:
The prosthetic valve is divided into multiple segments including a self-expanding frame with radial struts, ventricular anchors at the distal end, and commissure tabs, allowing for controlled deployment and accurate positioning through the catheter delivery system
Solution Approach 2:
The patent introduces a catheter delivery system as an intermediary that guides the compressed prosthetic valve to the target site and controls its expansion, enabling accurate anchoring in the mitral valve position without the difficulties associated with deploying large valves directly
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables effective minimally invasive treatment of mitral regurgitation with reduced recovery time, improved anchoring security, and potential for broader application across cardiac valves, addressing the limitations of existing treatments by providing a smaller, more easily deployable, and securely anchored prosthetic valve.
Implementation Method 1
a radially expandable frame having an expanded configuration, a collapsed configuration
Data Source
AI summary
A low-profile prosthetic valve for treating a native valve includes a radially expandable frame having an expanded configuration and a collapsed configuration. The atrial end of the prosthetic valve forms a flared shape that engages an atrial surface of the native valve. The flare shape flares downward toward a ventricle of the native valve when initially expanded followed by inversion of the flared shape to form a tapered shape tapering toward the ventricle and flaring toward the atrium of the native valve when fully expanded. The prosthetic valve also has a plurality of prosthetic valve leaflets that open and close to control fluid flow through the prosthetic valve.