Low-Temperature Roller Compaction for Dense, Flowable Coenzyme Q10
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Solution Overview
Problem
Existing methods for preparing coenzyme Q10 formulations face challenges due to its poor water solubility, instability, and poor rheological properties, leading to difficulties in handling and formulation, including poor bioavailability and substance losses during manufacturing.
Innovation Solution
A process involving roller compaction of coenzyme Q10 at temperatures between 10 °C and 25 °C, which results in compacted particles with improved flowability and handling properties, maintaining purity without additional excipients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If coenzyme Q10 is processed at temperatures above its melting point (48°C) to improve flowability, then handling properties improve, but substance decomposition and darkening occur due to heat exposure
Solution Approach 1:
The invention changes the temperature parameter from conventional high temperatures (>48°C) to low temperatures (10-25°C), fundamentally altering the processing conditions to avoid thermal decomposition while still achieving improved flowability through roller compaction at controlled low temperatures
Solution Approach 2:
The invention replaces thermal processing (heating above melting point) with mechanical processing (roller compaction), substituting a thermal system with a mechanical system that achieves particle densification and flowability improvement without thermal decomposition
2Ease of operation
If conventional roller compaction is performed at high temperatures to improve flowability, then handling improves, but CoQ10 decomposes and adheres to machinery surfaces
Solution Approach 1:
The invention inverts the conventional temperature parameter from high to low (10-25°C vs. >48°C), changing the physical state and properties of CoQ10 during processing to reduce adhesion while maintaining flowability improvements through mechanical compaction
3Ease of manufacture
If CoQ10 is processed without temperature control to simplify the process, then manufacturing is easier, but flowability and handling properties remain poor
Solution Approach 1:
The invention introduces temperature control as a critical parameter (10-25°C range) that enables both simplified processing (avoiding complex heating/cooling cycles) and improved flowability, optimizing the balance between manufacturing ease and product performance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compacted coenzyme Q10 particles exhibit enhanced flowability, higher density, and improved rheological properties, facilitating easier handling and manufacturing of pharmaceutical compositions while maintaining chemical integrity and purity.
Implementation Method 1
roller compaction of coenzyme Q10 at a temperature comprised between 10 °C and 25 °C
Data Source
Figure 1~2
AI summary
The invention relates to a process for manufacturing compacted coenzyme Q10 particles of high density and improved flowability comprising roller compaction of coenzyme Q10 at a temperature comprised between 10 °C and 30 °C. The invention also relates to the substantially pure compacted coenzyme Q10 obtainable with such process. The process of the invention allows obtaining compacted coenzyme Q10, with higher density and better flowability, which is advantageous for the preparation of pharmaceutical, dietary or cosmetic compositions. The invention also relates to the use of compacted coenzyme Q10 for preparing such compositions, to compositions comprising compacted coenzyme Q10 as active ingredient, and to compositions comprising compacted coenzyme Q10 either for use in therapy or for cosmetic use.