Low-Volume Liquid Filling Pump Selection by Shear Stress Modeling
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Solution Overview
Problem
Existing filling systems struggle to accurately and efficiently fill low volumes of liquids, particularly pharmaceutical or drug substances, due to issues like particle formation, mechanical stress, and the need for laborious setup and evaluation processes.
Innovation Solution
A process involving numerical modeling of flow patterns and shear stress rates to simulate and select the most appropriate liquid forwarding device for low volume filling, using computational fluid dynamics to evaluate and install the best pump type for aseptic conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional filling systems are used to fill low volumes of liquid drug substances, then filling can be performed, but particle formation occurs and dosing accuracy deteriorates
Solution Approach 1:
The patent applies preliminary action by conducting numerical simulations and evaluating liquid forwarding devices before actual filling operations. The system simulates flow patterns and calculates shear stress rates for different pump types, allowing selection of the most suitable device in advance, thereby preventing particle formation and dosing errors before they occur in production
Solution Approach 2:
The patent replaces physical trial-and-error testing with numerical simulations and computational models. Instead of mechanically testing different pump types with actual drug substances, the system uses CFD simulations to calculate flow patterns and shear stress, substituting mechanical experimentation with computational analysis to identify the most suitable liquid forwarding device
2Object-generated harmful factors
If extensive testing and evaluation of filling systems is performed to prevent particle formation, then particle-free filling can be achieved, but time consumption and labor increase
Solution Approach 1:
The patent replaces time-consuming physical testing with numerical simulations. The system uses computational fluid dynamics to simulate flow patterns and calculate shear stress rates for different liquid forwarding devices, eliminating the need for extensive manual testing and long-term studies while still ensuring particle-free filling
Solution Approach 2:
The patent performs preliminary evaluation through numerical simulations before actual filling operations. By calculating shear stress rates and analyzing flow patterns in advance, the system identifies the most suitable pump type beforehand, avoiding time-consuming trial-and-error testing during production setup
3Reliability
If overfilling is used to ensure sufficient drug substance administration, then dosing sufficiency is improved, but medication errors and waste increase
Solution Approach 1:
The patent applies hydraulic principles by analyzing flow patterns and shear stress rates in liquid forwarding devices. The system uses numerical simulations to optimize the hydraulic characteristics of different pump types, ensuring precise low-volume filling that delivers the exact required dose without overfilling, thereby preventing medication errors and drug waste
Solution Approach 2:
The patent changes operational parameters by evaluating different liquid forwarding devices based on their shear stress rates and flow characteristics. The system selects the pump type with optimal parameters for the specific liquid properties and filling requirements, enabling precise dosing without the need for overfilling margins
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for efficient, resource-saving selection of the most suitable liquid forwarding device, reducing particle formation and waste, and ensuring precise low volume filling without the need for extensive testing.
Implementation Method 1
determining a shear stress rate for each of the liquid forwarding devices based on the modelled flow patterns
Data Source
AI summary
A process of assembling a filling system for low volume filling of a liquid into a container is disclosed. The process includes obtaining plural liquid forwarding devices configured to provide the liquid from a reservoir to the container, and simulating operation of each of the liquid forwarding devices by numerically modelling flow patterns of the liquid when being forwarded by the liquid forwarding devices, and by determining a shear stress rate for each of the liquid forwarding devices based on the modelled flow patterns. The process further includes determining an appropriateness for each of the liquid forwarding devices by comparing operation parameters of the liquid forwarding of the liquid forwarding devices, wherein the operation parameters include the determined shear stress rates, selecting the liquid forwarding device having the highest determined appropriateness, and installing the selected liquid forwarding device into the filling system.