LTCC DNA Synthesis Substrate for High-Density Data Storage
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Solution Overview
Problem
Current DNA synthesis devices lack a suitable substrate that can efficiently support high-density, long-term digital data storage, as they do not utilize materials with the necessary thermal and electrical properties for stable and scalable DNA synthesis and reading.
Innovation Solution
A DNA synthesis substrate and device utilizing a low temperature co-fired ceramic support functionalized with a linker molecule, which forms bonds with nucleotides to synthesize single-stranded DNA oligomers, and a molecular electronics sensor for interpreting the encoded information, enabling efficient data storage and retrieval.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional substrates are used for DNA synthesis, then the synthesis process can proceed, but the substrate lacks the necessary thermal and electrical properties for stable and scalable high-density data storage
Solution Approach 1:
The patent changes the material parameters of the substrate by using low temperature co-fired ceramic (LTCC) instead of conventional substrates. LTCC provides specific thermal conductivity and electrical insulation properties that enable stable DNA synthesis while supporting high-density data storage applications, directly resolving the contradiction between synthesis stability and data storage suitability
Solution Approach 2:
The patent employs a composite structure consisting of LTCC substrate with integrated metal layers and functional coatings. This composite material approach combines the thermal stability of ceramic with the electrical conductivity of metal traces, creating a substrate that simultaneously supports DNA synthesis reactions and enables electrical reading of stored data
2Quantity of substance
If high-density DNA storage is implemented, then data storage capacity increases, but the substrate must provide enhanced thermal and electrical properties that conventional materials cannot provide
Solution Approach 1:
The LTCC substrate acts as an intermediary between the DNA oligomers and the underlying metal heating/reading layers. It provides thermal conduction for controlled DNA synthesis reactions while maintaining electrical insulation, enabling high-density storage with proper thermal management that conventional substrates cannot achieve
3Ease of manufacture
If a substrate is functionalized with linker molecules for DNA attachment, then DNA synthesis can occur, but the substrate material must support stable bonding and subsequent electrical reading
Solution Approach 1:
The patent applies local quality by functionalizing specific regions of the LTCC substrate with linker molecules at precise locations where DNA oligomers need to be synthesized. The LTCC material provides a stable surface for covalent bonding of linkers while maintaining overall substrate integrity for electrical reading, resolving the contradiction between ease of functionalization and bonding precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable and scalable method for DNA synthesis and reading, achieving high-density data storage with reduced errors and increased efficiency, leveraging the thermal and electrical properties of low temperature co-fired ceramic materials.
Implementation Method 1
low temperature co-fired ceramic support
Implementation Method 2
linker molecule functionalized to the low temperature co-fired ceramic support
Implementation Method 3
molecular electronics sensor that produces distinguishable signals in a measurable electrical parameter
Data Source
AI summary
Various aspects disclosed relate to a DNA synthesis substrate. the substrate includes a low temperature co-fired ceramic support. The substrate further includes a linker molecule functionalized to the low temperature co-fired ceramic support.