Lubabegron Formulations for Bovine Emission Reduction

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Solution Overview

Problem

Current methods for reducing ammonia and carbon dioxide emissions from bovines are costly, inconvenient, and of limited effectiveness, and existing solutions do not address the need for alternatives that do not negatively impact bovine muscle accumulation or meat quality.

Innovation Solution

Oral administration of lubabegron or its physiologically acceptable salts to bovines, either through feed additives or direct administration, to reduce ammonia and carbon dioxide emissions, with lubabegron being formulated into animal feeds or administered via drinking water to promote efficient emission reduction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-generated harmful factors

If dietary manipulation strategies are used to reduce ammonia and carbon dioxide emissions, then emission levels decrease, but bovine muscle accumulation and meat quality are negatively affected

Engineering Contradiction:
Improveammonia and carbon dioxide emissionsVSAvoidbovine muscle accumulation
Core Design Contradiction:
Object-generated harmful factorsVSStrength

Solution Approach 1:

The patent introduces lubabegron as an intermediary substance (beta-3 adrenergic receptor agonist) that mediates between emission reduction goals and muscle maintenance requirements. This pharmacological agent selectively targets fat metabolism without interfering with protein synthesis pathways, thereby reducing emissions while preserving muscle accumulation capacity

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the physiological parameters of bovine metabolism by administering lubabegron, which selectively activates beta-3 adrenergic receptors to increase lipolysis and fat oxidation. This parameter change allows the animal to emit fewer ammonia and carbon dioxide gases while maintaining normal protein metabolism and muscle growth rates

Inventive Principle:
Principle #35Parameter changes

2Object-generated harmful factors

If filtration and barrier methods are used to control ammonia emissions, then emission levels decrease, but operational convenience and cost-effectiveness worsen

Engineering Contradiction:
Improveammonia emissionsVSAvoidoperational convenience
Core Design Contradiction:
Object-generated harmful factorsVSEase of operation

Solution Approach 1:

The patent employs lubabegron to enable the bovine system to self-regulate ammonia emissions through pharmacological modulation of digestive and metabolic processes. The treated animal naturally reduces emissions without requiring external filtration infrastructure or barrier installations, thereby maintaining operational convenience while achieving emission control

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces mechanical emission control systems (filtration equipment, physical barriers) with a biochemical approach using lubabegron administration. This substitution eliminates the need for complex mechanical infrastructure, simplifying operations and reducing maintenance requirements while effectively controlling ammonia emissions

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentUS20240090533A1Methods and formulations for reducing bovine emissions
Publication Date: 2024.03.21 ELANCO US INC

AI summary

The present disclosure provides methods and formulations for reducing ammonia and carbon dioxide emissions from a bovine using lubabegron, or a physiologically acceptable salt thereof. The present disclosure also provides bovine feed additives and bovine feed compositions.