Lumen-Apposing Stent With Therapeutic Agent Delivery Against Migration
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Solution Overview
Problem
Current stents face challenges such as migration due to natural body movements, leading to fluid leakage and patient discomfort, and there is a need for improved mechanisms to secure and efficiently deliver therapeutic agents to the deployment site.
Innovation Solution
A system comprising a stent within sheaths, allowing transition between configurations, with a functional and/or therapeutic agent disposed between the sheaths, and a delivery device to inject the agent into the tissue volume defined by the stent and tissue wall, enhancing adhesion and therapeutic effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a stent is deployed in a body lumen to maintain fluid communication, then fluid flow is enabled, but the stent may migrate due to natural body movements such as peristalsis
Solution Approach 1:
The patent applies preliminary action by coating the stent with adhesive agents and therapeutic substances before deployment. The adhesive coating is prepared in advance on the stent surface, and the therapeutic agent is loaded into the stent structure prior to insertion. This preliminary preparation ensures that when the stent is deployed, the adhesive is already positioned to prevent migration and the therapeutic agent is ready for immediate delivery to the target site, resolving the contradiction between maintaining stent position and enabling therapeutic function.
2Reliability
If a stent is used to hold body tissues in apposition, then tissue closure is achieved, but mechanisms for secure and efficient delivery of therapeutic agents are needed
Solution Approach 1:
The patent merges multiple functions into a single stent device: structural support for tissue apposition, adhesive coating for migration prevention, and therapeutic agent delivery. The stent integrates the therapeutic agent reservoir or coating system with the structural framework, allowing simultaneous achievement of tissue closure stability and efficient therapeutic agent delivery through the same device, eliminating the need for separate delivery mechanisms.
Solution Approach 2:
The patent uses an adhesive coating as an intermediary substance that serves multiple purposes: it secures the stent to prevent migration, facilitates tissue apposition by bonding tissues together, and can be formulated to include or release therapeutic agents. This intermediary adhesive layer acts as a mediator that simultaneously achieves reliable tissue apposition and enables controlled therapeutic agent delivery to the target site.
3Reliability
If a stent is deployed to prevent migration, then position stability is improved, but mechanisms for targeted therapy delivery need to be enhanced
Solution Approach 1:
The patent applies local quality by providing different functional zones on the stent surface: adhesive-coated regions for migration prevention, therapeutic agent-loaded regions for targeted delivery, and potentially different coating densities or compositions in different areas. This localized functional differentiation allows the stent to simultaneously achieve position stability through adhesive anchoring and precise targeted therapy delivery through spatially controlled agent release at specific segments of the stent.
Data Source
Figure 1A~1B
Figure 2A~2C
Figure 2D
AI summary
Devices, systems, and methods for delivering targeted therapy to tissue at a treatment site with the use of a stent. The targeted therapy may include a functional and/or therapeutic agent separate from the stent, or a component of a functional and/or therapeutic agent separate from the stent and reactive with another component of a functional and/or therapeutic agent on the stent. The agent or component of an agent may be delivered with the stent, and/or before delivery of the stent, and/or after the stent has been delivered.