Microencapsulated Lutein Composition for Retinal Blue Light Protection
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Solution Overview
Problem
Current medicinal and edible dual-purpose compositions fail to effectively address retinal blue light damage due to poor solubility and bioavailability of lutein, and lack comprehensive protection against blue light-induced oxidative stress and inflammation.
Innovation Solution
A composition using whey protein isolate and polyphenols, noncovalently cross-linked with procyanidine and bilberry anthocyanin, microencapsulated with lutein, deep sea fish oil, and maltodextrin, processed into nano-emulsions via shearing and homogenization, followed by spray drying to enhance solubility and stability, and then pressed into tablets for improved bioavailability and anti-inflammatory effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If lutein is used as a functional raw material to protect against blue light damage, then antioxidant function is improved, but solubility and bioavailability are poor
Solution Approach 1:
The patent uses whey protein isolate as a carrier material to form a composite system with lutein. The protein carrier improves the solubility and bioavailability of lutein while maintaining its antioxidant function. This composite approach allows lutein to be effectively delivered and absorbed in the body without sacrificing its protective properties.
Solution Approach 2:
The patent modifies the physical and chemical parameters of lutein by incorporating it into a protein-based delivery system. This changes the solubility characteristics and bioavailability parameters of lutein, transforming it from a poorly soluble compound to a bioavailable functional ingredient that can be effectively utilized in the body.
2Reliability
If lutein is used to protect retinal pigment epitheliums from photooxidation, then eye protection function is improved, but lutein is easily degraded by environmental factors
Solution Approach 1:
The patent applies beforehand cushioning by using whey protein isolate to pre-protect lutein from degradation by environmental factors such as light, oxygen, and temperature. The protein carrier acts as a protective barrier that shields lutein during storage and processing, ensuring its stability while maintaining its eye protection function.
3Device complexity
If direct tablet pressing method is used to simplify production process, then manufacturing complexity is reduced, but moisture content and component requirements are higher
Solution Approach 1:
The patent changes the moisture content parameter of the tablet formulation by incorporating lutein-protein complexes that have different moisture requirements compared to raw lutein. This parameter modification allows the use of direct tablet pressing method while maintaining product quality and stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method increases the bioavailability of lutein, providing effective antioxidant and anti-inflammatory effects, significantly alleviating and preventing retinal damage caused by blue light exposure, with no side effects and a stable, efficient production process.
Implementation Method 1
procyanidine and bilberry anthocyanin, which have excellent anti-oxidation function, are noncovalently cross-linked with protein
Implementation Method 2
mixing the oil phase with the aqueous phase, and performing shearing emulsification and homogenization to obtain a nano-emulsion
Implementation Method 3
removing moisture from the nano-emulsion obtained in step S3 by a spray drying method
Data Source
AI summary
The disclosure discloses a medicinal and edible dual-purpose composition capable of resisting retinal blue light damage, and a preparation method and application. The medicinal and edible dual-purpose composition capable of resisting retinal blue light damage disclosed by the disclosure includes the following components in parts by weight: 40-60 parts of a microencapsulated nutrient component, 1-3 parts of a sweetening agent, 10-20 parts of microcrystalline cellulose, and 0.5-2 parts of magnesium stearate. The medicinal and edible dual-purpose composition product is simple and quick in preparation. By adding the microencapsulated nutrient component, the stability and bioavailability of procyanidine, bilberry anthocyanin and lutein are remarkably increased, synergistic anti-inflammatory and anti-oxidation functions of the procyanidine, bilberry anthocyanin and lutein are fully played, the problems of retinal damage and the like caused by LED blue light irradiation can be prevented and improved, and wide application prospects and economic benefits are achieved.