Non-invasive LV Filling Pressure Estimation via Imaging
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Solution Overview
Problem
Current methods for assessing blood pressure inside the heart, particularly for diagnosing heart failure with preserved ejection fraction (HFpEF), are invasive and require hospital visits, limiting early diagnosis and treatment.
Innovation Solution
A non-invasive system using imaging data and patient-specific parameters to estimate left ventricular (LV) filling pressure, which includes obtaining cardiac markers and calculating LV filling pressure through a statistical analysis of historic patient data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive pressure catheter methods are used to measure LV filling pressure, then measurement precision is improved, but ease of operation deteriorates and loss of time increases
Solution Approach 1:
The patent replaces the mechanical invasive pressure catheter system with a non-invasive imaging-based system using echocardiography and MRI to obtain cardiac markers, which are then processed through statistical models and machine learning algorithms to estimate LV filling pressure, thereby eliminating the need for invasive procedures while maintaining diagnostic accuracy
Solution Approach 2:
The patent introduces cardiac markers (such as LA reservoir strain, LV isovolumic pressure decay time constant, and other imaging-derived parameters) as intermediary variables that bridge the gap between non-invasive imaging data and LV filling pressure estimation, allowing indirect measurement without direct catheter contact
2Measurement precision
If invasive heart catheterization is performed to assess cardiac function, then measurement precision is improved, but loss of time worsens due to hospital visit requirements
Solution Approach 1:
The patent enables preliminary assessment of LV filling pressure using routine non-invasive imaging tests that can be performed during regular outpatient visits, allowing early detection and monitoring of HFpEF without requiring dedicated hospital admission for catheterization procedures
3Ease of operation
If non-invasive imaging methods are used to estimate LV filling pressure, then ease of operation is improved, but measurement precision deteriorates
Solution Approach 1:
The patent combines multiple different imaging modalities (echocardiography, MRI) and multiple cardiac markers (LA reservoir strain, LV isovolumic pressure decay, E/e' ratio, and other hemodynamic parameters) into a composite assessment model, where the combination of diverse data sources compensates for individual limitations and improves overall measurement precision
Solution Approach 2:
The patent transforms imaging data into multiple derived cardiac markers and parameters through statistical analysis and machine learning algorithms, converting raw imaging measurements into clinically relevant hemodynamic estimates that improve precision beyond direct imaging measurements alone
Data Source
AI summary
A system and method for estimating LV filling pressure of the heart of a human patient. The system includes a data processing apparatus, an imaging system for non-invasively obtaining images of the patient's heart and for providing imaging data to the data processing apparatus, and a data input device for receiving patient specific parameters relating to BMI and systolic arterial blood pressure of the patient and for providing the patient specific parameters to the data processing apparatus. The data processing apparatus is configured to perform the method including the steps of using the imaging data and the patient specific parameters, determining an estimate of the minimum LV diastolic pressure, estimating the peak pressure drop and obtaining a maximum difference between the LA pressure and LV pressure, and calculating an estimate of the LV filling pressure.