Lycium barbarum and Moringa oleifera Composition for Skin Damage
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Solution Overview
Problem
Current preparations for preventing or treating skin damage caused by excessive ultraviolet radiation exposure often result in side effects, and there is a need for effective solutions that address both aesthetic and health risks associated with photoaging and precancerous lesions.
Innovation Solution
A composition combining Lycium barbarum extract or its polysaccharide with Moringa oleifera extract, in specific ratios, to provide a synergistic cellular antioxidant effect that reduces oxidative stress and protects against skin damage from UV radiation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If preparations containing antioxidant substances of vegetal origin (such as curcumin or epigallocatechin-gallate) are used to counteract ROS-induced skin damage, then antioxidant protection is improved, but side effects (contact allergy, abdominal pain, nausea) worsen
Solution Approach 1:
The patent extracts and uses only the essential active components (polyphenols and polysaccharides) from vegetal sources through standardized extraction processes, eliminating unwanted constituents that cause side effects while preserving antioxidant activity. This is achieved through controlled extraction methods that isolate beneficial compounds from the plant matrix.
Solution Approach 2:
The patent modifies the chemical parameters of antioxidant substances by controlling molecular weight ranges (polyphenols: 150-500 Da, polysaccharides: 10-100 kDa) and purity levels, thereby optimizing biological activity while reducing immunogenicity and side effects associated with higher molecular weight or less purified extracts.
2Stability of the object's composition
If the skin antioxidant system is relied upon to neutralize ROS, then endogenous protection is maintained, but during aging and excessive UV exposure the system becomes insufficient and oxidative damage worsens
Solution Approach 1:
The patent applies exogenous antioxidants before UV exposure occurs, establishing a protective reservoir of polyphenols and polysaccharides in the skin that preemptively neutralize ROS generation. This preliminary reinforcement of antioxidant defenses prevents oxidative damage before it can occur during subsequent UV exposure events.
Solution Approach 2:
The patent combines exogenous plant-derived antioxidants (polyphenols and polysaccharides) with the body's endogenous antioxidant systems, creating a synergistic multi-layered defense mechanism. The plant compounds work alongside endogenous enzymes and molecules to provide comprehensive protection that exceeds the capacity of either system alone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination effectively reduces cellular oxidative stress, protects human keratinocyte cell lines, and treats or prevents actinic damage, precancerous lesions, and non-melanoma skin cancer, while minimizing side effects, thereby addressing the challenges of photoaging and skin health risks.
Implementation Method 1
by combining one or more components of a Lycium barbarum extract with components from a Moringa oleifera extract in the ratio defined in claim 1, a synergistic cellular antioxidant effect which reduces cellular oxidative stress is obtained
Data Source
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AI summary
The present invention concerns a composition comprising a Lycium barbarum extract or Lycium barbarum polysaccharide in combination with a Moringa oleifera extract and a pharmaceutically acceptable carrier. The composition finds application both in the medical field, in the treatment of actinic lesions, precancerous skin lesions, or non-melanoma skin cancer, and in non-therapeutic applications in the treatment of skin damage caused by exposure to the sun's rays, such as photoaging.