Lycopene Isomerization Catalyst Stability Bioavailability
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Solution Overview
Problem
Current carotenoid-based products, such as lycopene from tomato sources, have limited bioavailability due to their isomeric profiles, with 13-Z lycopene being less stable and reducing overall stability and bioavailability, while existing solutions only slightly enhance Z-isomer content without addressing stability issues.
Innovation Solution
A composition enriched in 5-Z and 9-Z lycopene isomers with a low 13-Z isomer content, achieved through isomerization using solid catalysts or prolonged heating, to enhance stability and bioavailability, formulated into food, cosmetic, or pharmaceutical products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If thermal processing is used to promote isomerization and increase Z-isomers, then bioavailability is improved, but stability deteriorates due to retro-isomerisation
Solution Approach 1:
The patent applies parameter changes by carefully controlling temperature, time, and catalyst conditions during thermal processing to achieve optimal isomerization. By adjusting these parameters, the process maximizes Z-isomer formation while minimizing retro-isomerisation, thus improving bioavailability without sacrificing stability.
Solution Approach 2:
The patent uses catalysts as intermediaries to facilitate isomerization. The catalyst enables the conversion of all-E lycopene to Z-isomers under milder conditions, reducing the need for aggressive thermal processing that would cause stability issues. The catalyst mediates the reaction to achieve desired isomer profile while maintaining product stability.
2Reliability
If high Z-isomer content is achieved through isomerization, then bioavailability increases, but manufacturing complexity increases
Solution Approach 1:
The patent employs catalysts as intermediaries to simplify the isomerization process. The catalyst enables efficient conversion to Z-isomers under controlled conditions, reducing the need for complex multi-step processing while achieving the desired isomer profile for improved bioavailability.
Solution Approach 2:
The patent optimizes processing parameters such as temperature, time, and catalyst concentration to achieve efficient isomerization in a single step. By carefully controlling these parameters, the process achieves high Z-isomer content without requiring complex manufacturing equipment or multiple processing stages.
3Productivity
If 13-Z isomer is present in high amounts, then isomerization efficiency is improved, but stability deteriorates significantly
Solution Approach 1:
The patent adjusts processing parameters to control the distribution of different Z-isomers. By optimizing temperature, time, and catalyst conditions, the process favors the formation of stable Z-isomers (5-Z and 9-Z) over the unstable 13-Z isomer, achieving both efficient isomerization and product stability.
Solution Approach 2:
The patent applies local quality by targeting the formation of specific Z-isomer types. The isomerization process is controlled to preferentially produce stable 5-Z and 9-Z isomers while minimizing 13-Z isomer formation, creating a differentiated isomer profile that balances productivity and stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition exhibits improved stability and bioavailability, maintaining isomer profiles during storage and increasing bioavailability by up to twice that of traditional tomato paste, specifically enhancing skin health and potentially preventing cardiovascular diseases and cancers.
Implementation Method 1
isomerization using solid catalysts or prolonged heating
Implementation Method 2
Thermal isomerisation of lycopene is known to improve its bioavailability from food matrices
Data Source
AI summary
The present invention relates to a method of manufacturing a stable composition enriched in cis-lycopene (z-isomers) by prolonged heating in solvents of tomatoes, parts of tomatoes, derivative thereof or tomato extracts in solvents.