Lymphangiogenesis-Inducing Device for Controlled Tissue Wound Creation

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Solution Overview

Problem

Current treatments for lymphedema, such as combined physical therapy and lymphaticovenular anastomosis, are either conservative and burdensome for patients or require advanced surgical techniques with limited availability and potential complications.

Innovation Solution

A lymphangiogenesis inducing device with a puncture member and a rod-shaped body featuring a wound imparting structure to create fine wounds in the tissue, promoting new lymphatic vessel growth without complex procedures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If lymphaticovenular anastomosis is performed, then radical treatment of lymphedema is achieved, but advanced plastic surgical techniques are required and the opportunity to receive treatment is limited

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidsurgical complexity
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces complex manual surgical anastomosis techniques with a mechanically assisted device system. The puncture member and rod-shaped body with protrusions create controlled mechanical wounds that guide lymphatic vessel regeneration, substituting the need for advanced manual surgical skills with a standardized mechanical intervention process.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The device enables the body's own lymphatic system to perform the healing and regeneration work. By creating controlled wounds with the rod-shaped body, the treatment triggers the body's natural lymphangiogenesis process, allowing the organism to self-repair without requiring continuous external surgical intervention or highly skilled ongoing management.

Inventive Principle:
Principle #25Self-service

2Reliability

If lymphaticovenular anastomosis is performed, then radical treatment is achieved, but unified procedure has not been determined and quality of anastomosis affects the result

Engineering Contradiction:
Improvetreatment consistencyVSAvoidprocedural standardization
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent standardizes critical procedural parameters through its device design. The puncture member diameter, rod-shaped body dimensions, and protrusion characteristics are fixed to create consistent wound patterns. This parameter standardization ensures reproducible treatment outcomes regardless of operator skill level, establishing a unified procedure with controlled variables.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The device creates a standardized template for wound creation that can be replicated across different patients and operators. The rod-shaped body with specific protrusion patterns serves as a physical copy or model of the ideal wound configuration, ensuring consistent treatment delivery and eliminating variability in anastomosis quality.

Inventive Principle:
Principle #26Copying

3Ease of operation

If combined physical therapy is used, then conservative treatment is provided, but it does not improve symptoms and daily self-care burden is large

Engineering Contradiction:
Improvepatient burdenVSAvoidsymptom improvement
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The device performs preliminary structural intervention by creating controlled wounds that pre-establish the conditions for lymphatic vessel regeneration. This preliminary mechanical action prepares the tissue pathway in advance, allowing the body to naturally complete the regeneration process without requiring ongoing conservative therapy or daily self-care interventions.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent extracts the essential therapeutic function from complex conservative therapy regimens. By isolating and amplifying the key stimulus (controlled mechanical wound creation) that triggers lymphangiogenesis, the device removes the need for multiple concurrent conservative therapies and daily patient self-care activities, delivering the core beneficial effect through a single procedural intervention.

Inventive Principle:
Principle #2Taking out (Extraction)

Data Source

PatentUS12349913B2Lymphangiogenesis inducing device
Publication Date: 2025.07.08 TERUMO KK
  • US12349913B2 patent drawing
  • US12349913B2 patent drawing
  • US12349913B2 patent drawing

AI summary

A method of forming a wound for inducing lymphangiogenesis includes: providing a lymphangiogenesis inducing device that includes: a puncture member including a distal end portion configured to puncture living tissue, and a through hole penetrating the puncture member along a central axis and extending from the distal end portion toward a proximal end, and a rod-shaped body inserted into the through hole and configured to be moved so as to protrude from the distal end portion, where the rod-shaped body includes a shaft portion, and a wound imparting structure; puncturing the living tissue with the lymphangiogenesis inducing device while the rod-shaped body is located in the through hole; passing the lymphangiogenesis inducing device through a regeneration route; pulling back the puncture member while the rod-shaped body is left in the living tissue; and pulling back the rod-shaped body.