Lyophilized Hydrogel Wound Dressing With Layered Hydration Control

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Solution Overview

Problem

Existing hydrogel wound dressings lack a structured approach to vary water content and fluid absorption capacities across multiple layers, which affects their efficacy in maintaining a moist environment and providing antimicrobial protection for wound healing.

Innovation Solution

A multi-layered lyophilized hydrogel wound dressing with varying water content layers, sealed in a barrier, and removable interleaved sheets to maintain hydration gradients and enhance antimicrobial activity at the wound surface.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If hydrogel wound dressings are made with high water content to provide moisture to the wound, then the wound surface can be kept hydrated, but the structural integrity and stability of the dressing deteriorates

Engineering Contradiction:

Improvewater contentVSAvoidstructural integrity

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The hydrogel dressing is divided into multiple layers with different water content levels. The first layer has lower water content (providing structural stability) while subsequent layers have progressively higher water content (providing moisture to the wound). This segmentation allows each layer to perform its specific function without compromising the overall dressing integrity.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different regions of the dressing (different layers) are assigned different water content properties. The layer adjacent to the wound bed has higher water content to provide moisture, while the outer layers have lower water content to maintain structural stability. This local differentiation of properties resolves the contradiction between hydration and stability.

Inventive Principle:

Principle #3Local quality

2Reliability

If hydrogel wound dressings are made with varying water content layers to improve hydration distribution, then wound healing is enhanced, but the manufacturing complexity increases

Engineering Contradiction:

Improvehydration consistencyVSAvoidmulti-layered structure

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The dressing is constructed as multiple stacked layers, each with controlled water content. This segmentation enables consistent hydration delivery to different areas of the wound while maintaining a relatively simple manufacturing process of layer-by-layer assembly.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The dressing uses composite hydrogel structures with varying water content in different layers. This composite approach allows the dressing to provide consistent hydration across the wound surface while using commercially available hydrogel materials that can be processed using standard techniques.

Inventive Principle:

Principle #40Composite materials

3Quantity of substance

If removable interleaved barrier sheets are added to maintain water content in each layer, then hydration levels are preserved, but the device complexity and ease of operation are reduced

Engineering Contradiction:

Improvewater content maintenanceVSAvoidapplication simplicity

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The barrier sheets are pre-placed between the hydrogel layers during manufacturing to prevent water migration. This preliminary action ensures that each layer maintains its designated water content without requiring additional steps during application, thus preserving hydration levels while minimizing impact on ease of operation.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Removable interleaved barrier sheets act as intermediaries between the hydrogel layers to prevent water content degradation. These barrier sheets are designed to be easily removed before application, serving their protective function during storage and transport while allowing straightforward application of the dressing to the wound.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The multi-layered structure provides a controlled hydration gradient and sustained antimicrobial protection, promoting wound healing by maintaining a moist environment and preventing degradation of active ingredients.

Implementation Method 1

a diffusion-based delivery system that remains effective without frequent changes

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

A wound dressing composition having a first layer of a lyophilized hydrogel layer

Methodology Applied

Scientific EffectFreeze drying: Freeze Drying

Data Source

PatentUS12616774B2Lyophilized hydrogel wound dressing

Publication Date: 2026.05.05 BONE PHARM LLC

AI summary

A wound dressing composition having a first layer of a lyophilized hydrogel layer having hydrolyzed collagen and hydrolyzed hyaluronic acid ingredients, wherein the first layer has a water content of 10 percent or less and is configured to lay onto a wound. The first layer can be cut or molded to various shapes such as a rectangle, a square, a polygon, an oval or a circle. The first layer is hermetically sealed in a cover or barrier and placed in final packaging. Alternatively, one or more additional layers are stacked onto the first layer, each additional one or more layers having a water content greater than that of the first layer.