Lyophilized TAT-NR2B9c Formulation for Stroke Treatment
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Solution Overview
Problem
Current treatments for stroke and ischemic conditions often require immediate diagnosis to administer medication, but existing formulations are not stable enough for prehospital use, limiting their availability at the scene of an incident.
Innovation Solution
A lyophilized formulation of TAT-NR2B9c, combined with histidine and trehalose, which is stable at room temperature and can be reconstituted with an aqueous solution, allowing for administration before reaching a medical facility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current stroke treatment formulations are used, then immediate diagnosis and administration is required, but the formulations are not stable enough for prehospital use
Solution Approach 1:
The patent changes the physical and chemical parameters of the TAT-NR2B9c formulation by adjusting pH to 6-7 and adding specific excipients (histidine and trehalose), transforming it from an unstable liquid formulation to a stable lyophilized solid formulation that can be stored at room temperature without refrigeration
Solution Approach 2:
The patent utilizes lyophilization (freeze-drying) to transition the formulation from liquid phase to solid phase, creating a stable lyophilized cake that can be stored at room temperature and then reconstituted with aqueous solution immediately before administration, enabling prehospital use
2Stability of the object's composition
If lyophilized formulation is prepared, then room temperature stability is achieved, but reconstitution process is required
Solution Approach 1:
The formulation is prepared in advance as a lyophilized cake with all necessary excipients (histidine buffer and trehalose) already incorporated, so that upon arrival at the medical facility, only simple reconstitution with aqueous solution is needed, eliminating the need for complex preparation steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation maintains stability and potency, enabling effective treatment of stroke and ischemic conditions even in emergency settings without the need for immediate diagnosis, reducing infarction size and functional deficits.
Implementation Method 1
A lyophilized formulation of TAT-NR2B9c, combined with histidine and trehalose, which is stable at room temperature
Implementation Method 2
reconstituted with an aqueous solution, allowing for administration before reaching a medical facility
Data Source
AI summary
The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at room temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.