Lys-Thr Dipeptides for Stable Anti-Aging Cosmetics
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Solution Overview
Problem
Current cosmetic solutions for skin aging, such as those containing vitamins and plant extracts, often have stability issues and do not consistently deliver promised results, particularly in addressing wrinkles and skin elasticity loss.
Innovation Solution
The use of dipeptides with threonine as the C-terminal amino acid, specifically Lys-Thr and its derivatives, which provide superior properties compared to dipeptides with serine, when used in cosmetic and dermatological formulations to treat signs of skin aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If dipeptides with serine as C-terminal amino acid are used, then the cosmetic composition can be formulated, but the dermopharmaceutical and cosmetic activity is inadequate
Solution Approach 1:
The patent changes the C-terminal amino acid residue from serine to threonine in the dipeptide structure. This parameter change in the molecular structure transforms Lys-Ser into Lys-Thr, which provides superior dermopharmaceutical and cosmetic activity for treating skin aging signs, including wrinkles and loss of elasticity.
2Reliability
If vitamins and plant extracts are used in cosmetic formulations, then the cosmetic composition can provide moisturizing and anti-wrinkle effects, but the formulations have stability problems and do not consistently deliver promised results
Solution Approach 1:
The patent replaces unstable natural ingredients (vitamins and plant extracts) with a structurally defined dipeptide Lys-Thr. This parameter change in ingredient selection provides a stable, consistent formulation that reliably delivers anti-aging effects without the stability issues associated with natural extracts.
Data Source
AI summary
Dipeptides and derivatives and analogs, such as Pal-KT have been developed. These dipeptides, derivatives and analogs may be used alone or in an additive, to produce cosmetics, topical pharmaceuticals and personal care products, particularly for skin care. Methods of making the dipeptides, derivatives, analogs and additives containing same are also described.