L-lysine Feed Additive Granules Stability
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Solution Overview
Problem
Current methods for producing L-lysine-containing animal feed additives from fermentation broths are inefficient, leading to high lysine loss and unsuitable granules due to hygroscopicity and caking issues, and often result in complex and costly production processes.
Innovation Solution
A method involving acidification of the fermentation broth to a pH of 4.0 to 5.2 and adjusting the sulphate/L-lysine ratio to 0.85 to 1.2, followed by dehydration and granulation, which reduces lysine loss and improves granule stability and whiteness, while maintaining a high L-lysine content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If crude fermentation broth is spray-dried to produce solid concentrate, then L-lysine content is concentrated, but the product becomes very hygroscopic, dusty, and lumpy after short storage time
Solution Approach 1:
The patent changes the chemical composition parameters of the fermentation broth by adjusting the sulphate/L-lysine ratio to 0.68-0.95 and controlling the anion composition. This parameter modification prevents hygroscopicity and caking during storage while maintaining high L-lysine content (30-60% by weight), thus resolving the contradiction between concentration and stability.
2Manufacturing precision
If complex production steps are used to produce pure L-lysine monohydrochloride, then high purity product is obtained, but large amounts of byproducts and reagents are generated as waste
Solution Approach 1:
The patent extracts only the essential components needed for product stability (specific sulphate/L-lysine ratio and anion composition) from the complex fermentation broth, eliminating the need for extensive purification steps. This allows direct production of stable granulated feed additive from crude broth, reducing both processing complexity and waste generation.
Solution Approach 2:
The fermentation broth itself provides the necessary components for product stability through its natural composition. By controlling the sulphate/L-lysine ratio and anion composition within specified ranges, the system uses its own constituents to prevent hygroscopicity and caking, eliminating the need for additional stabilizing agents or complex purification processes.
3Reliability
If fermentation broth is acidified and stabilised with bisulphite before concentration, then product stability is improved, but lysine loss occurs during workup
Solution Approach 1:
The patent optimizes the pH range to 3.5-5.1 and controls the sulphate/L-lysine ratio to 0.68-0.95, which creates conditions for product stability without requiring bisulphite addition. This parameter optimization reduces lysine loss during workup while maintaining stability, eliminating the need for harmful stabilizing agents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces lysine loss by approximately 50% and produces granules with improved stability and reduced hygroscopicity, making them more suitable for use as animal feed additives.
Implementation Method 1
A method involving acidification of the fermentation broth to a pH of 4.0 to 5.2
Implementation Method 2
followed by dehydration and granulation
Implementation Method 3
followed by dehydration and granulation
Data Source
AI summary
The invention relates to relatively light and thermally stable granulated, fermentation-broth-based animal feed additives having a high content of L-lysine and to low-loss methods for their production from broths obtained by fermentation.