Lysophospholipid Composition Using Polyhydric Alcohol Enzymolysis

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Solution Overview

Problem

Existing methods for decomposing phospholipids using phospholipase A require organic solvents, which are not suitable for food applications and result in slow enzymolysis rates, necessitating a new method that avoids solvents and enhances reaction efficiency.

Innovation Solution

A method involving enzymolysis of phospholipids in a polyhydric alcohol-based mixture with controlled ratios of phospholipid, fat and oil, polyhydric alcohol, and pure water to produce a lysophospholipid with self-emulsifying properties, using phospholipase A without organic solvents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If phospholipid is decomposed using phospholipase A in organic solvent, then enzymolysis reaction rate is improved, but the product cannot be used for food applications and requires solvent removal

Engineering Contradiction:
Improveenzymolysis reaction rateVSAvoidorganic solvent presence
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The invention changes the solvent parameter from organic solvent to polyhydric alcohol (such as glycerin), which maintains high enzymolysis reaction rates while being safe for food applications. This parameter substitution resolves the contradiction by finding an alternative solvent that satisfies both productivity and safety requirements

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention uses polyhydric alcohol as a replacement solvent that does not require removal, effectively treating the solvent as a final component of the product rather than a temporary medium requiring elimination. This approach eliminates the harmful factor of organic solvent presence while maintaining reaction efficiency

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Object-affected harmful factors

If phospholipid is decomposed in oil-in-water emulsion without organic solvent, then food application safety is improved, but enzymolysis reaction rate becomes slower and large amount of energy is required for water removal

Engineering Contradiction:
Improvefood application safetyVSAvoidenzymolysis reaction rate
Core Design Contradiction:
Object-affected harmful factorsVSProductivity

Solution Approach 1:

The invention changes the dispersion medium parameter from water-based emulsion to polyhydric alcohol-based system. This parameter change simultaneously improves enzymolysis reaction rate while maintaining food safety and eliminating the need for energy-intensive water removal processes

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention introduces polyhydric alcohol as an intermediary substance that facilitates the enzymolysis reaction more effectively than water-based systems. The polyhydric alcohol acts as a superior medium that enhances enzyme activity and reaction kinetics while being safe for food applications

Inventive Principle:
Principle #24Intermediary (Mediator)

3Adaptability or versatility

If phospholipid is decomposed in polyhydric alcohol-based mixture with controlled ratios, then self-emulsifying properties are achieved, but requires precise control of mixing ratios

Engineering Contradiction:
Improveself-emulsifying propertiesVSAvoidmixing ratio control
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The invention establishes specific parameter ranges for mixing ratios (phospholipid: 0.07-0.5 times total lipid, polyhydric alcohol: 0.4-3.0 times water content) that enable self-emulsifying properties. By defining these parameter ranges, the invention balances the need for precise control with the achievement of desired functional properties

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method achieves high phospholipid decomposition ratios and self-emulsifying properties, enabling versatile applications in food, pharmaceuticals, and cosmetics without solvent removal, and facilitates the production of oil-in-water emulsions.

Implementation Method 1

the enzymolysis of the phospholipid by phospholipase A proceeds without using an organic solvent accompanied by removal

Methodology Applied
Scientific EffectEnzymolysis: Enzyme

Implementation Method 2

decomposing a phospholipid with phospholipase A

Methodology Applied
Scientific EffectHydrolysis: Hydrolysis

Implementation Method 3

the lysophospholipid-containing composition to be obtained has self-emulsifying properties

Methodology Applied
Scientific EffectSelf-emulsification: Emulsion

Data Source

PatentEP4585693A1Method for producing lysophospholipid-containing composition and method for producing oil-in-water emulsion composition using same
Publication Date: 2025.07.16 Q P CORP
  • EP4585693A1 patent drawing
  • EP4585693A1 patent drawing

AI summary

The present invention relates to a method for producing a lysophospholipid-containing composition in which a phospholipid is decomposed by phospholipase A, the method includes a mixing step, a phospholipid enzymolysis step, and an enzyme inactivation step, a value calculated by a L2 value - a L1 value is positive in the lysophospholipid-containing composition. the L1 value: a brightness value of the composition, the L2 value: a brightness value of an oil-in-water emulsion obtained by dispersing the composition in 100 times by mass of pure water In the mixing step, a total amount of a phospholipid, a fat and oil, a polyhydric alcohol, pure water, and phospholipase A used is 90% by mass or more with respect to a total amount of the raw materials and the phospholipase A, a content of the polyhydric alcohol in the raw materials is 0.4 to 3.0 times by mass with respect to a content of the pure water, a content of the phospholipid in the raw materials is 0.07 to 0.5 times by mass with respect to a total content of the phospholipid and the fat and oil, and a total amount of the polyhydric alcohol and the pure water in the raw materials is 0.25 to 4.0 times by mass with respect to the total content of the phospholipid and the fat and oil.