Magnetic Torquer Conjugate Drug for Non-Invasive Neuromodulation
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Solution Overview
Problem
Existing neuromodulation methods lack spatiotemporal specificity and invasiveness, limiting their effectiveness in treating neurological and metabolic disorders.
Innovation Solution
Development of a Magnetic Torquer (m-Torquer) conjugate-based drug comprising magnetic nanoparticles that generate rotational force upon a controlled rotating magnetic field, with a binding moiety to target proteins in biological membranes, enabling non-invasive modulation of ion channels and neural activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional chemical drugs are administered orally or by injection, then therapeutic effects are achieved, but systemic circulation causes undesirable side effects
Solution Approach 1:
The patent applies local quality by using a binding moiety that specifically targets and binds to drug target proteins present in the biological lipid membrane of specific cells. This localization ensures that the magnetic nanoparticle delivers its mechanical force only to the intended target site, achieving therapeutic effects while avoiding systemic side effects through precise spatial selectivity.
Solution Approach 2:
The patent uses a binding moiety as an intermediary between the magnetic nanoparticle and the drug target protein. This intermediary enables specific recognition and binding to the target, allowing the magnetic nanoparticle to selectively interact with diseased cells or tissues while leaving healthy cells unaffected, thus resolving the contradiction between therapeutic efficacy and side effect reduction.
2Adaptability or versatility
If electroceuticals are used to modulate neural signals, then metabolic functions are regulated, but implantation is required which increases invasiveness
Solution Approach 1:
The patent replaces the implanted electrical stimulation system with a mechanically actuated magnetic nanoparticle system. Instead of using electrical fields requiring implants, the invention uses magnetically controlled mechanical torque applied by nanoparticles that bind to target proteins, achieving neuromodulation through mechanical force transmission without invasive implantation.
Solution Approach 2:
The patent extracts the essential function of electroceuticals (neuromodulation and metabolic regulation) from the invasive implantation requirement. By using systemically administrable magnetic nanoparticles that target specific proteins, the invention separates the therapeutic function from the delivery mechanism, eliminating the need for implants while maintaining metabolic regulation capability.
3Ease of operation
If magnetic nanoparticles are used to generate rotational force, then non-invasive neuromodulation is achieved, but working distance from the magnetic field generator must be sufficient
Solution Approach 1:
The patent applies parameter changes by optimizing the magnetic field generator design to produce a rotating magnetic field with sufficient intensity and appropriate frequency at working distances of at least 1 cm (preferably 20-70 cm). This enables non-invasive operation while maintaining effective torque generation on the magnetic nanoparticles through careful control of magnetic field parameters.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The m-Torquer conjugate allows precise, non-invasive neuromodulation of specific neuronal populations, effectively regulating feeding behavior and weight management in animal models, offering a promising therapeutic approach for obesity and other metabolic disorders.
Implementation Method 1
a magnetic nanoparticle that generates rotational force upon application of a controlled rotating magnetic field
Implementation Method 2
the rotational force generated by the magnetic nanoparticle upon application of a controlled rotating magnetic field is transmitted to the drug target protein
Data Source
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AI summary
The present invention relates to a Magnetic Torquer (m-Torquer) conjugate-based drug. Specifically, according to the present invention, an m-Torquer conjugate, comprising: (a) a magnetic nanoparticle that generates rotational force upon application of a controlled rotating magnetic field, wherein the working distance from the rotating magnetic field generator is at least 1 cm, preferably at least 2 cm, 10 cm, more preferably at least 20 cm, 30 cm, and most preferably at least 60 cm or 70 cm; (b) a binding moiety that binds to a drug target protein present in the biological lipid membrane; and (c) a linker or a direct attachment between the magnetic nanoparticle and the binding moiety, wherein, when the m-Torquer conjugate binds to the drug target protein, the rotational force generated by the magnetic nanoparticle upon application of a controlled rotating magnetic field is transmitted to the drug target protein, inducing a conformational change in the drug target protein. Accordingly, the m-Torquer conjugate-based drug may be used as a therapeutic agent that modulates biological signaling, structural integrity, metabolism, function, and regulation in the body.