Machine-Learned Microbial Knowledgebase for Cancer Risk Reduction
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Solution Overview
Problem
Current methods for identifying microbes or microbial functions that affect cancer risk are limited and often rely on costly, harmful products, ignore microbial competition, and lack targeted cancer prevention strategies, leading to ineffective and harmful treatments.
Innovation Solution
A system and method for creating a knowledgebase of microbes and microbial functions using machine learning techniques to label, sequence, and annotate good and bad strains based on competitive traits, generating prediction models to identify and store beneficial microbes, and applying them with nutritional modulation for cancer risk reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional chemotherapy and radiotherapy are used to treat cancer, then cancer cells are killed, but serious side effects occur and normal health deteriorates
Solution Approach 1:
The patent introduces microbiota as an intermediary mediator between cancer treatment and host health. Beneficial microbes modulate the immune system and stress response pathways, enabling cancer treatment to proceed with reduced harm to normal tissues. The microbes act as a buffer that protects host health while maintaining treatment effectiveness.
Solution Approach 2:
The patent converts the harmful effects of cancer and its treatment into beneficial outcomes by using stress response modulation. The same stress pathways that are activated by cancer and treatment are harnessed and redirected through microbial intervention to produce anti-cancer effects while protecting normal health.
2Object-affected harmful factors
If existing cancer prevention products like thymosin or cerium oxide nanoparticles are used, then side effects of treatment are reduced, but these products are costly and some are inherently harmful requiring attenuation
Solution Approach 1:
The patent uses naturally occurring beneficial microbes that are inexpensive, readily available, and self-limiting. These microbes provide their protective function and then naturally die off or maintain themselves as part of the normal microbiota, eliminating the need for costly, attenuated, or inherently harmful products.
Solution Approach 2:
The beneficial microbes are self-sufficient and do not require attenuation or modification to be safe. They naturally regulate their own activity through their metabolic processes and interactions with the host microbiota, providing protection without generating harmful effects that would require additional intervention.
3Ease of manufacture
If microbial strains are selected without considering competitive traits, then simple selection methods are used, but the competitive nature of microbes in the host is ignored reducing effectiveness
Solution Approach 1:
The patent changes the selection parameters from simple taxonomic classification to functional traits related to microbial competition. Specific parameters such as bacteriocin production, resource utilization efficiency, and stress tolerance are used to identify strains that can effectively compete in the host microbiota environment, thereby improving prevention effectiveness.
Data Source
AI summary
Many microbes are capable of synthesizing anti-cancer products, however existing state of art is limited by focus on industrial production of the said products. A method and system for preparing a knowledgebase of microbes and microbial functions to identify good and bad microbes have been provided. The present disclosure therefore further describes methods and compositions for the risk assessment, prevention and management of various forms of cancer by using microbes, microbial products utilizing the knowledgebase of microbes and microbial function. The method is configured to priming the microbes inside the host for boosting the immune response against cancer initiation, progression, recurrence and associated side effects. The use of microbes and microbial products can be provided in the form of probiotics, supplements, and prebiotics etc. along with creation of right sets of nutrition conditions in the host for the proper functioning of the microbes and microbial products.