Macroencapsulation Device Implantation Handling and Storage
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Solution Overview
Problem
Existing methods for handling macroencapsulation devices during transport and implantation often fail to protect these devices from damaging forces and contamination, which can render them unfit for implantation.
Innovation Solution
A macroencapsulation implantation device with a receptacle featuring an internal channel and a recess for housing the macroencapsulation device, along with a handle and pusher mechanism that minimizes forces applied during implantation, and a container system for storing the device with appropriate media to maintain cell viability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If macroencapsulation devices are handled during transport and implantation, then implantation can be performed, but the devices are exposed to damaging forces and contamination
Solution Approach 1:
The macroencapsulation device is nested within a receptacle that is integrated into the implantation device. The receptacle has an internal channel and recess that securely holds the macroencapsulation device, protecting it from external forces and contamination during handling and implantation procedures.
Solution Approach 2:
The receptacle acts as an intermediary between the macroencapsulation device and the external environment. It provides a protected interface that allows the device to be handled and implanted while minimizing direct exposure to damaging forces and contamination sources.
2Reliability
If a receptacle with internal channel and recess is designed to house the macroencapsulation device, then protection from damage is improved, but device complexity increases
Solution Approach 1:
The receptacle's protective features (internal channel, recess, and locking mechanism) are merged into a single integrated component that attaches to the implantation device. This combination provides comprehensive protection while minimizing the number of separate parts and overall structural complexity.
Solution Approach 2:
The receptacle is designed with segmented functional zones: an internal channel for positioning, a recess for housing the macroencapsulation device, and a locking mechanism for securing. This segmentation allows each feature to perform its specific protective function efficiently without unnecessary complexity.
3Manufacturing precision
If a pusher mechanism is used to displace the macroencapsulation device through the distal opening, then implantation precision is improved, but the risk of applying damaging forces increases
Solution Approach 1:
The pusher mechanism applies force locally and selectively - only to the macroencapsulation device when needed for implantation, while the receptacle and handle remain stationary. This localized action provides precise positioning control while minimizing the transmission of damaging forces to the device.
Solution Approach 2:
The pusher mechanism provides dynamic control over the implantation process, allowing the operator to apply force only when the macroencapsulation device needs to be displaced through the distal opening. The locking mechanism can be engaged or disengaged as needed, providing flexible and controlled force application.
Data Source
AI summary
Macroencapsulation implantation devices and containers for storing a macroencapsulation device disposed within a receptacle of a macroencapsulation implantation device as well as related methods are described. In some embodiments, a macroencapsulation implantation device may include a handle that is configured to be selectively engaged with a receptacle including a recess in which a macroencapsulation device may be disposed. In some embodiments, a container may be configured to maintain a receptacle of a macroencapsulation implantation device, and a macroencapsulation device disposed therein, in a desired pose within an internal volume of the container.