Macroporous Hydroxyapatite Composite for Faster Bone Regeneration

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Solution Overview

Problem

Existing bone regeneration materials based on natural hydroxyapatite are not optimal for accelerating bone regeneration and often result in insufficient bone formation due to prolonged regeneration times and inadequate microporosity, even when modified with tricalcium phosphate, which compromises the structural integrity and porosity of the material.

Innovation Solution

A bone regeneration material comprising a first solid phase of macroporous hydroxyapatite of natural origin enriched with a second solid synthetic phase of calcium phosphate, maintaining optimal porosity and topography, and promoting calcium and phosphorus salting-out as free ions to enhance bone cell proliferation and differentiation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If natural hydroxyapatite is used as bone regeneration material, then biocompatibility and osteoconductive properties are improved, but bone regeneration time is prolonged and bone formation is insufficient

Engineering Contradiction:

ImprovebiocompatibilityVSAvoidbone regeneration time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent combines natural hydroxyapatite with synthetic calcium phosphate to create a composite material that leverages the biocompatibility of natural hydroxyapatite while utilizing the faster resorption and ion-release properties of synthetic calcium phosphate to accelerate bone regeneration

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the chemical composition parameters by controlling the Ca/P molar ratio of the synthetic calcium phosphate phase (between 0.2 and 2) and the weight ratio between hydroxyapatite and calcium phosphate (between 99/1 and 1/99), optimizing both biocompatibility and regeneration speed

Inventive Principle:

Principle #35Parameter changes

2Productivity

If tricalcium phosphate is added to hydroxyapatite to accelerate regeneration, then bone formation is enhanced, but structural integrity and porosity are compromised

Engineering Contradiction:

Improvebone formation rateVSAvoidstructural integrity

Core Design Contradiction:

ProductivityVSStrength

Solution Approach 1:

The patent specifies precise parameter ranges for the Ca/P molar ratio of calcium phosphate (0.2 to 2) and weight ratio (99/1 to 1/99) to control the balance between acceleration of bone formation and preservation of structural integrity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent maintains macroporous structure with interconnected pores of 50-100 μm in the hydroxyapatite phase, ensuring that the synthetic calcium phosphate is distributed in a way that preserves local structural quality while providing sites for ion release and bone cell infiltration

Inventive Principle:

Principle #3Local quality

3Ease of operation

If macroporous structure with large pores is used, then bone colonization is facilitated, but mechanical strength is reduced

Engineering Contradiction:

Improvebone colonizationVSAvoidmechanical strength

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

The patent utilizes a macroporous structure with interconnected pores of 50-100 μm that facilitates bone cell infiltration and vascularization while the synthetic calcium phosphate phase provides structural support to maintain mechanical strength

Inventive Principle:

Principle #31Porous materials

Solution Approach 2:

The composite structure combines the bone-colonization advantage of macroporous hydroxyapatite with the structural reinforcement provided by synthetic calcium phosphate, achieving both ease of bone colonization and adequate mechanical strength

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The material significantly reduces bone regeneration time and ensures optimal bone formation by maintaining structural integrity and porosity, facilitating rapid bone colonization and regeneration.

Implementation Method 1

promoting calcium and phosphorus salting-out as free ions to enhance bone cell proliferation and differentiation

Methodology Applied

Scientific EffectIon release:

Implementation Method 2

promoting calcium and phosphorus salting-out as free ions

Methodology Applied

Scientific EffectSalting-out:

Implementation Method 3

a first solid phase of hydroxyapatite of natural origin which is macroporous having pores of diameters greater than or equal to 50 μm

Methodology Applied

Scientific EffectPorosity: Porosity

Implementation Method 4

These interconnections constitute types of 'tunnels' which make it possible for the passage of cells and blood circulation between the pores thus encouraging bone formation

Methodology Applied

Scientific EffectCell migration:

Implementation Method 5

hydroxyapatite of natural origin has osteoconductive properties as well as a crystalline structure and a morphology identical to those of a natural bone material in humans

Methodology Applied

Scientific EffectOsteoconduction:

Implementation Method 6

hydroxyapatites (and in particular, hydroxyapatites of natural origin) have good biocompatibility and specific adsorption properties of cells or proteins

Methodology Applied

Scientific EffectBiocompatibility:

Data Source

PatentUS20250352698A1Bone regeneration material

Publication Date: 2025.11.20 WISHBONE

AI summary

A bone regeneration material containing a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, and a solid synthetic second phase of calcium phosphate intended to enrich the first phase and having a Ca/P molar ratio of between 0.2 and 2 is provided. The bone regeneration material has a defined weight ratio of the solid first phase of hydroxyapatite of natural origin to the solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.