Magnesium Ascorbate Composition for Higher Absorption With Fewer GI Effects

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Solution Overview

Problem

There is a need for bioavailable magnesium compositions to increase magnesium levels in subjects, as poor dietary intake and gastrointestinal or kidney issues lead to magnesium deficiency, which increases the risk of illnesses such as high blood pressure, heart disease, diabetes mellitus type 2, and osteoporosis.

Innovation Solution

Administering a magnesium source, such as magnesium salts or chelates, in combination with ascorbate, particularly magnesium ascorbate, at a ratio of 1:1 to 5:1, either in a single composition or separately within 15 minutes, to enhance absorption via the gastrointestinal tract.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If magnesium is administered alone, then magnesium levels may be increased, but absorption is insufficient and gastrointestinal side effects occur

Engineering Contradiction:

Improvemagnesium absorptionVSAvoidgastrointestinal side effects

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

Ascorbic acid serves as a mediator that facilitates magnesium absorption by forming a soluble complex with magnesium ions in the gastrointestinal tract. This intermediary mechanism allows magnesium to be absorbed more efficiently without directly causing gastrointestinal irritation, thereby resolving the contradiction between increasing magnesium absorption and reducing gastrointestinal side effects

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite system where magnesium (as magnesium ions or magnesium salts) is combined with ascorbic acid to form a soluble complex. This composite approach enhances the bioavailability of magnesium while the ascorbic acid component protects against gastrointestinal side effects, simultaneously achieving both improvement goals

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If conventional magnesium supplements are used, then magnesium intake is provided, but bioavailability is low due to poor absorption

Engineering Contradiction:

Improvemagnesium bioavailabilityVSAvoidabsorption efficiency

Core Design Contradiction:

Quantity of substanceVSProductivity

Solution Approach 1:

The invention changes the chemical parameters of magnesium supplementation by combining magnesium with ascorbic acid. This parameter change transforms insoluble or poorly absorbable magnesium forms into a soluble complex that can be efficiently absorbed in the gastrointestinal tract, thereby improving both bioavailability and absorption efficiency

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method increases magnesium absorption by at least 55% and reduces gastrointestinal side effects, effectively addressing magnesium deficiency and related health issues.

Implementation Method 1

The magnesium source may include a magnesium salt or a magnesium chelate. The ascorbate may be from ascorbic acid or an ascorbate salt, such as magnesium ascorbate.

Methodology Applied

Scientific EffectChelation:

Implementation Method 2

The magnesium source and the ascorbate may be formulated into a single composition. The magnesium source and the ascorbic acid may be administered separately, but within 15 minutes of each other.

Methodology Applied

Scientific EffectSolvation: Solvation

Data Source

PatentUS12496289B2Methods of increasing magnesium bioavailability and absorption

Publication Date: 2025.12.16 BALCHEM CORP

AI summary

The present disclosure relates to compositions and methods of increasing magnesium bioavailability and absorption.