Magnesium-Doped Hydroxyapatite for Enhanced Biocompatibility
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Solution Overview
Problem
Conventional hydroxyapatite biomaterials used in applications such as food additives, cosmetic ingredients, and artificial bones lack the high biocompatibility required for advanced applications.
Innovation Solution
Hydroxyapatite containing magnesium (Mg) with microcrystalline structure and optionally including minerals like Na, K, and Si, formulated using biologically derived materials to enhance biocompatibility and adsorption capacity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional hydroxyapatite is used, then it provides basic biocompatibility, but it lacks the high biocompatibility required for advanced applications
Solution Approach 1:
The patent changes the chemical composition parameters of hydroxyapatite by incorporating magnesium ions (Mg2+) at specific concentrations (1-3 atomic percent), which transforms the material from having basic biocompatibility to exhibiting high biocompatibility suitable for advanced medical applications
Solution Approach 2:
The patent creates a composite hydroxyapatite material by combining calcium hydroxyapatite with magnesium ions, forming a Mg-doped hydroxyapatite composite that exhibits enhanced biocompatibility and osteogenic properties not present in conventional hydroxyapatite
2Quantity of substance
If hydroxyapatite is made with microcrystalline structure, then adsorption capacity increases, but manufacturing complexity increases
Solution Approach 1:
The patent controls the crystalline structure parameters by controlling particle size and crystallinity during synthesis, creating a microcrystalline structure that maximizes surface area and adsorption capacity while using optimized synthesis conditions to manage manufacturing complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Mg-containing hydroxyapatite exhibits higher biocompatibility and adsorption capacity, suitable for applications like filter materials and teeth whitening, with improved safety and reduced irritation due to its fine particle size and smooth texture.
Implementation Method 1
hydroxyapatite containing Mg... (Ca:Mg)10(PO4)6(OH)2 wherein (Ca:Mg)10 denotes that the total number of Ca atoms and Mg atoms equals to 10, with the number of Ca atoms being from 7 to 9, and the number of Mg atoms being from 1 to 3
Implementation Method 2
a site for inducing precipitation of hydroxyapatite crystals is incorporated into a substrate and the substrate is immersed in an aqueous solution containing a hydroxyapatite component, to thereby precipitate hydroxyapatite crystals on the surface of the substrate
Implementation Method 3
a substrate is coated or printed by predetermined hydroxyapatite dispersion, and then the solvent contained in the hydroxyapatite dispersion is evaporated from the substrate to thereby generate low crystalline hydroxyapatite particles on the surface of the substrate
Data Source
AI summary
Hydroxyapatite having high biocompatibility suitable for applications such as food additives, cosmetic ingredients, pharmaceutical ingredients, and artificial bones is provided. The hydroxyapatite of the present invention contains Mg.