Magnesium Hydride Toothpaste for Chronic Periodontitis Treatment

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Solution Overview

Problem

Current toothpastes are inadequate in providing sustained prevention and treatment for chronic periodontitis, with commercially available options having short service life and potential side effects from traditional Chinese medicine additives, and lacking dual functions of healthcare and treatment.

Innovation Solution

A magnesium hydride toothpaste formulation with 1% to 3% magnesium hydride, which reacts to release hydrogen and magnesium ions for disinfection, anti-inflammation, and alveolar bone inhibition, combined with other ingredients like glycerin, calcium carbonate, and peppermint powder for effective whitening and symptom alleviation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If peroxide is added to toothpaste for disinfection, then the oral environment can be kept healthy, but the toothpaste has a single function and short service life

Engineering Contradiction:
Improvedisinfection effectVSAvoidfunctionality
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies magnesium hydride as a multi-functional ingredient that simultaneously provides disinfection, anti-inflammatory effects, and alveolar bone resorption inhibition. This replaces the single-function peroxide approach with a compound that addresses multiple periodontal disease aspects, thereby increasing adaptability and versatility while maintaining reliability.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Reliability

If traditional Chinese medicine ingredients are used for disinfection, then anti-bacterial and anti-inflammatory effects are achieved, but obvious side effects occur and the product cannot enter the international market

Engineering Contradiction:
Improvedisinfection effectVSAvoidside effects
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent transitions from traditional Chinese medicine ingredients to magnesium hydride, changing the chemical composition parameter to achieve comparable disinfection and anti-inflammatory effects while eliminating the side effects associated with TCM additives. This parameter change enables international market entry while maintaining therapeutic reliability.

Inventive Principle:
Principle #35Parameter changes

3Ease of operation

If toothpaste is used for daily cleaning, then oral hygiene is maintained, but sustained prevention and treatment of chronic periodontitis is inadequate

Engineering Contradiction:
Improvedaily cleaning functionVSAvoidservice life
Core Design Contradiction:
Ease of operationVSDuration of action of moving object

Solution Approach 1:

The patent incorporates magnesium hydride that continuously releases hydrogen and magnesium ions during the toothpaste's service life. This continuous release mechanism sustains disinfection, anti-inflammatory, and bone protection effects over an extended period, transforming the short service life of conventional toothpaste into a sustained therapeutic action that lasts throughout the product's usage cycle.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The magnesium hydride toothpaste effectively prevents and treats chronic periodontitis by reducing gingival bleeding, swelling, bad breath, and removing tooth stains, with low cost and no toxic side effects, as demonstrated by clinical trials and bactericidal activity tests.

Implementation Method 1

magnesium hydride has a weight percentage of 1% to 3%... magnesium hydride toothpaste has the effects of disinfection, anti-inflammation

Methodology Applied
Scientific EffectChemical reaction: Chemical Bonding

Implementation Method 2

inhibition of alveolar bone resorption... preventing and treating chronic periodontitis

Methodology Applied
Scientific EffectBiological effect:

Implementation Method 3

As small molecules, hydrogen molecules can freely penetrate tissues and cells to reach any location

Methodology Applied
Scientific EffectDiffusion: Diffusion

Data Source

PatentUS12121601B2Use of magnesium hydride in preparation of composition for preventing and treating chronic periodontitis, and magnesium hydride toothpaste
Publication Date: 2024.10.22 SHANGHAI JIAOTONG UNIV

AI summary

The-use of magnesium hydride in the preparation of a composition for preventing and treating chronic periodontitis, and a magnesium hydride toothpaste are provided. In the composition or the magnesium hydride toothpaste, magnesium hydride has a weight percentage of 1% to 3%. The toothpaste has the functions of disinfection, anti-inflammation, anti-oxidation, removing tooth stains, improving bad breath, alleviating gingival swelling, bleeding, and recession, and improving periodontitis symptoms. An appropriate amount of magnesium hydride fine particles is added in toothpaste, and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with anti-inflammatory effects, which can also inhibit alveolar bone resorption. The magnesium hydride-containing composition is safe in use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.