Magnesium Ketoboswellic Acid L-Tryptophan Composition for Muscle Relaxation
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Solution Overview
Problem
Current treatments for muscle, bone, and articular pathologies often fail to effectively address muscle pain, contracture, and inflammation, particularly in post-traumatic rehabilitation, due to limitations in muscle relaxation and anti-inflammatory effects.
Innovation Solution
A pharmaceutical composition combining magnesium, L-tryptophan, and ketoboswellic acid, such as 3-acetyl-11-keto-β-boswellic acid (AKBA), which provides both muscle-relaxant and anti-inflammatory effects, formulated for oral administration to treat muscle distension, stiffness, and tension.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for muscle pathologies are used, then muscle pain and contracture are addressed, but anti-inflammatory effects are insufficient
Solution Approach 1:
The patent combines three distinct active ingredients (magnesium, L-tryptophan, and ketoboswellic acid) into a single pharmaceutical composition. This merging of multiple substances with complementary mechanisms of action resolves the contradiction by providing both reliable anti-inflammatory effects (from ketoboswellic acid) and effective muscle relaxation (from magnesium and L-tryptophan), thereby improving overall treatment effectiveness for muscle pathologies.
2Stability of the object's composition
If magnesium is used as muscle relaxant, then muscle elasticity is improved, but nerve conduction may be affected
Solution Approach 1:
The patent applies local quality by using magnesium specifically for its muscle-relaxant properties while combining it with L-tryptophan and ketoboswellic acid to address nerve conduction and inflammation separately. This allows magnesium to improve muscle elasticity locally without compromising overall nerve conduction reliability, as the other ingredients compensate for any potential magnesium-induced effects on nerve function.
3Reliability
If L-tryptophan is used to improve mood and sleep, then stress and anxiety are reduced, but muscle stiffness may persist
Solution Approach 1:
The patent merges L-tryptophan (for mood and sleep improvement) with magnesium (for muscle relaxation) and ketoboswellic acid (for anti-inflammatory effects) in a single composition. This combination ensures that while L-tryptophan addresses stress and anxiety, magnesium simultaneously targets muscle stiffness, resolving the contradiction by providing both psychological and physiological benefits in one treatment.
4Reliability
If ketoboswellic acid is used for anti-inflammatory activity, then inflammation is reduced, but muscle relaxation may be insufficient
Solution Approach 1:
The patent combines ketoboswellic acid (for anti-inflammatory activity) with magnesium and L-tryptophan (both with muscle-relaxant properties) in a single pharmaceutical composition. This merging ensures that while ketoboswellic acid provides reliable anti-inflammatory effects, magnesium and L-tryptophan simultaneously deliver effective muscle relaxation, resolving the contradiction by providing both therapeutic actions in one formulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of magnesium, L-tryptophan, and ketoboswellic acid in the composition demonstrates synergistic effects, significantly reducing inflammation and muscle contractions, thereby improving muscle function and pain management in a safe and effective manner.
Implementation Method 1
Magnesium is a mineral involved in various biochemical reactions and plays a crucial role in the production and use of energy. It is considered to be of valuable assistance as regards the muscular system (cofactor necessary for ensuring muscle elasticity and physiological sliding of the myofibrils)
Implementation Method 2
key role in nerve conduction as it is an active element in many types of channels that ensure physiological transmission of the action potential in the case of functionality of the tissue
Implementation Method 3
magnesium thus indirectly regulates the cytoplasmic calcium concentration, which is interesting activity since calcium is an essential element both for contraction (sarcoplasmatic calcium) and for nerve conduction and for maintaining the membrane potential
Implementation Method 4
magnesium is responsible for maintaining the physiological functions of the nervous system. These are post-synaptic receptors, which are physiologically slower than the AMPA and KA receptors (the other two types) and are highly permeable to calcium. Opening of the channel requires the attainment of a particular action potential, which may be reached by means of the presence of magnesium, which blocks the channel until the threshold is reached.
Implementation Method 5
The composition that is the subject of the present invention also comprises the dry extract of Boswellia serrata. Boswellia serrata is characterized by the presence, in the plant complex, of numerous bioactive substances, such as ketoboswellic acids. The latter are reported in the literature for their anti-inflammatory, immunomodulatory, antitumoral and antiasthmatic activities.
Implementation Method 6
L-tryptophan, which is a known precursor of serotonin and melatonin, which are responsible for the tone of the mood (serotonin directly and melatonin indirectly by improving the sleep cycle)
Data Source
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AI summary
A pharmaceutical composition or dietary supplement having a muscle-relaxant and anti¬ inflammatory activity is described, which is effective in the treatment of muscle, bone, articular and tendon pathologies, comprising, as active ingredients, a combination of magnesium, at least one ketoboswellic acid and L-tryptophan.