Magnesium Lactate Fermentation Process with Controlled Crystal Concentration

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Solution Overview

Problem

Current magnesium lactate fermentation processes face challenges in maintaining stable operation and efficient product separation while achieving high productivity and quality, with conventional methods often resulting in decreased productivity due to high or low magnesium lactate concentrations, and difficulties in separating solid magnesium lactate from the fermentation broth.

Innovation Solution

A fermentation process that maintains a solid magnesium lactate concentration between 5-40 vol% for at least 40% of the operating time, allowing for efficient product separation and high yield, by periodically removing and recycling magnesium lactate crystals from the fermentation broth, which can be adjusted in batch, fed-batch, or continuous processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If magnesium lactate concentration is increased to improve productivity, then volumetric productivity improves, but product separation becomes more difficult

Engineering Contradiction:
Improvevolumetric productivityVSAvoidproduct separation
Core Design Contradiction:
ProductivityVSEase of manufacture

Solution Approach 1:

The patent applies dynamic control of magnesium lactate concentration by adjusting operational parameters (feed rate, pH, temperature) to maintain concentration within the optimal 5-40 vol% range throughout the fermentation process, allowing the system to adapt and maintain both high productivity and separability

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent changes the concentration parameter of magnesium lactate from uncontrolled high levels to a controlled range of 5-40 vol%, which fundamentally alters the separation characteristics while maintaining productivity. This parameter optimization enables effective solid-liquid separation

Inventive Principle:
Principle #35Parameter changes

2Ease of manufacture

If magnesium lactate concentration is decreased to improve product separation, then filtration properties improve, but volumetric productivity decreases

Engineering Contradiction:
Improvefiltration propertiesVSAvoidvolumetric productivity
Core Design Contradiction:
Ease of manufactureVSProductivity

Solution Approach 1:

The patent optimizes the magnesium lactate concentration parameter to a specific range (5-40 vol%) that balances filtration properties with productivity. This parameter change ensures crystals are present in sufficient quantities for high productivity while maintaining separability

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent maintains continuous presence of solid magnesium lactate crystals throughout the fermentation process by controlling concentration to remain above 5 vol%, ensuring both continuous productivity and continuous separability without interruption

Inventive Principle:
Principle #20Continuity of useful action

3Manufacturing precision

If solid magnesium lactate is removed during fermentation to maintain concentration, then product quality improves, but process complexity increases

Engineering Contradiction:
Improveproduct qualityVSAvoidprocess complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent employs self-service separation where solid magnesium lactate crystals naturally settle and are removed through simple decantation or filtration without requiring complex intervention systems. The process uses the inherent properties of the crystallizing product to achieve separation

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach ensures good process stability and high product quality by maintaining optimal magnesium lactate concentrations, improving filtration properties and enabling effective separation from contaminants, thus achieving high volumetric productivity and commercial viability.

Implementation Method 1

fermenting the fermentation medium by means of a lactic acid producing microorganism in the presence of an alkaline magnesium salt to provide a fermentation broth comprising magnesium lactate

Methodology Applied
Scientific EffectFermentation: Fermentation

Implementation Method 2

recovering solid magnesium lactate from the magnesium lactate containing fermentation broth

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Data Source

PatentUS11661614B2Magnesium lactate fermentation process
Publication Date: 2023.05.30 PURAC BIOCHEM BV

AI summary

A fermentation process for producing magnesium lactate from a carbon source including the steps of: providing a fermentation medium including a fermentable carbon source in a fermentation reactor; fermenting the fermentation medium by a lactic acid producing microorganism in the presence of an alkaline magnesium salt to provide a fermentation broth including magnesium lactate; and recovering solid magnesium lactate from the magnesium lactate containing fermentation broth, wherein during at least 40% of the operating time of the fermentation process, the concentration of solid magnesium lactate in the fermentation broth is maintained in the range of 5-40 vol. %, calculated as solid magnesium lactate crystals on the total of the fermentation broth. The process allows stable operation at high productivity, in combination with efficient product separation.