Magnesium Lithospermate B Purification via Preliminary Action
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Solution Overview
Problem
Current methods for preparing high purity magnesium lithospermate B are inefficient, resulting in low yields and high production costs, with no reported pharmaceutical compositions using substantially pure magnesium lithospermate B as an active component.
Innovation Solution
A process involving the extraction and purification of magnesium lithospermate B from Salvia miltiorrhiza plant materials using added magnesium salts, chromatography on macroporous absorption resin, and organic solvent extraction to achieve high purity (>95%) with improved yield.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional extraction methods are used to obtain magnesium lithospermate B, then the purification process can be simplified, but the purity and yield are limited (50-95% with high cost)
Solution Approach 1:
Magnesium salts are added to the extraction system before the main purification process to pre-form magnesium lithospermate B complexes, ensuring high purity is achieved from the outset rather than requiring extensive post-extraction purification
Solution Approach 2:
The extraction process utilizes controlled pH conditions and specific alcohol-water solvent ratios to optimize the formation and extraction efficiency of magnesium lithospermate B, achieving both high purity and high yield simultaneously
2Manufacturing precision
If extensive purification steps are implemented to achieve high purity, then the purity increases, but the production cost and process complexity increase significantly
Solution Approach 1:
By adding magnesium salts in advance to form well-defined complexes, the subsequent purification requires only standard chromatography steps rather than multiple specialized purification stages, reducing overall process complexity
Solution Approach 2:
Magnesium salts act as intermediary compounds that facilitate selective complex formation with lithospermate B, enabling straightforward separation from other plant constituents through conventional chromatographic methods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process significantly increases the yield of high purity magnesium lithospermate B, reducing production costs and enabling its use in pharmaceutical compositions with enhanced biological activity and stability.
Implementation Method 1
separating the Salvia miltiorrhiza liquid extract or the concentrated Salvia miltiorrhiza extract liquid via chromatography on macroporous absorption resin
Implementation Method 2
extracting with an organic solvent to give a raffinate comprising magnesium lithospermate B
Data Source
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AI summary
The present invention relates to a method for preparing magnesium lithospermate B. The method is characterized in that: magnesium lithospermate B is extracted or purified from a Salvia miltiorrhiza plant material or a Salvia miltiorrhiza extract in the presence of an added magnesium salt. The present invention also relates to a high-purity magnesium lithospermate B product prepared by the method of the present invention, wherein the content of magnesium lithospermate B is more than 95% by weight.