Bioabsorbable Magnesium Stent Graft for Vessel Patency
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Solution Overview
Problem
Current implantable medical devices in body vessels face issues with thrombosis and platelet deposition, leading to reduced patency rates and medical complications, particularly due to the material properties of existing stents which can irritate blood vessels and cause inflammation.
Innovation Solution
Development of medical devices with a bioabsorbable metallic frame, such as magnesium alloys, attached to a remodelable extracellular matrix material, which provides a thromboresistant surface, reduces elastic recoil, and dissolves within the body vessel over time, promoting tissue remodeling and minimizing inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a non-bioabsorbable metallic frame is used in implantable medical devices, then mechanical strength and structural stability are improved, but thrombosis and platelet deposition increase, leading to reduced patency rates
Solution Approach 1:
The patent changes the material parameter from non-bioabsorbable metal to bioabsorbable metallic alloy (magnesium-based), fundamentally altering the interaction with blood vessels. This material parameter change reduces thrombosis and platelet deposition while maintaining adequate mechanical strength during the healing period, thereby improving patency rates.
Solution Approach 2:
The patent employs composite construction by attaching remodelable extracellular matrix material to the bioabsorbable metallic frame. This composite structure combines the mechanical strength of the metallic alloy with the biological compatibility and thromboresistance of the extracellular matrix, simultaneously addressing both strength requirements and patency concerns.
2Object-affected harmful factors
If a bioabsorbable metallic frame is used, then thrombosis is reduced and tissue remodeling is promoted, but the frame dissolves within the body vessel over time requiring monitoring
Solution Approach 1:
The patent introduces dynamic behavior to the implant by using bioabsorbable materials that change their physical state over time. The metallic frame progressively dissolves and is absorbed by the body, transitioning from a permanent structural element to a temporary scaffold that promotes healing and then disappears, eliminating the need for long-term durability.
Solution Approach 2:
The patent applies the concept of disposable or temporary implants by using bioabsorbable metallic alloys that are designed to dissolve within a specific time frame. This allows the frame to perform its function during the critical healing period and then be naturally absorbed, eliminating the need for permanent structural integrity.
3Strength
If existing stent materials are used, then structural support is provided, but inflammation and irritation of blood vessels occur
Solution Approach 1:
The patent changes the material composition parameter from conventional non-bioabsorbable metals to bioabsorbable magnesium-based alloys with controlled dissolution characteristics. This parameter change reduces inflammation and vascular irritation while maintaining adequate structural support during the healing period, as the material gradually dissolves without causing significant inflammatory response.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bioabsorbable metallic frame with remodelable graft material reduces thrombosis, maintains vessel patency, and promotes biological processes like tissue growth, while minimizing inflammation and the need for surgical extraction.
Implementation Method 1
a bioabsorbable metallic frame, such as magnesium alloys, attached to a remodelable extracellular matrix material, which provides a thromboresistant surface, reduces elastic recoil, and dissolves within the body vessel over time
Data Source
AI summary
The medical devices, such as stent grafts, described herein preferably include a tubular remodelable graft material attached to a support frame formed at least in part from a metallic bioabsorbable material. The remodelable graft material preferably includes an extracellular matrix material such as small intestinal submucosa (SIS). The support frame attached to the graft is preferably a bioabsorbable magnesium alloy. The devices may be implanted within a peripheral vascular body vessel from a percutaneous delivery catheter.