Magnet Width Uniformity in Sample Analysis Channels
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Solution Overview
Problem
Existing sample analysis devices face challenges in uniformly capturing magnetic particles, leading to inefficient B/F separation, poor luminescence sensitivity, and measurement inaccuracies due to non-uniform magnetic field distribution, particularly at the channel side walls.
Innovation Solution
The device features a magnet with a wider width than the detection channel, ensuring a more uniform magnetic field gradient, which enhances the capture of magnetic particles throughout the channel, including the side walls, thereby improving capture efficiency and measurement accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If magnetic particles are captured at a predetermined position using a magnet, then the antigen amount can be detected, but the magnetic particles are not uniformly captured especially at the channel side walls leading to poor measurement accuracy
Solution Approach 1:
The magnet is designed with different magnetic field strengths at different locations. The magnetic field is stronger at the channel center and weaker at the side walls, creating local variations in capture force that compensate for the flow distribution and achieve uniform magnetic particle capture across the entire channel cross-section
Solution Approach 2:
The magnetic field parameter is varied across the channel cross-section by optimizing the magnet geometry and position. This creates a non-uniform magnetic field distribution that balances the flow velocity and particle capture efficiency, ensuring uniform capture density throughout the channel
2Manufacturing precision
If the magnet width is made wider than the channel width, then uniform magnetic field distribution is achieved, but the device complexity increases
Solution Approach 1:
Instead of using a uniformly strong magnetic field throughout, the magnet is designed with localized magnetic field variations. The field strength is optimized at specific locations within the channel to achieve uniform particle capture, rather than simply making the entire magnet wider
Solution Approach 2:
The magnet position and configuration are optimized to dynamically balance the magnetic force with the flow characteristics. This allows achieving uniform capture with a compact magnet design rather than requiring excessive magnet width
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration results in improved B/F separation, washing efficiency, measurement accuracy, and reproducibility by ensuring uniform particle capture and increased luminescence intensity.
Implementation Method 1
a magnet with a wider width than the detection channel, ensuring a more uniform magnetic field gradient, which enhances the capture of magnetic particles throughout the channel
Implementation Method 2
by using a laser, the luminescent substance bound to the magnetic particles emits luminescence
Implementation Method 3
The immunoassay is a test that uses specific antigen-antibody reaction to detect or measure antibodies or antigens in humor
Data Source
Figure 1(a)~1(b)
Figure 2(a)~2(b)
Figure 3~4
AI summary
A problem of a sample analysis device that uses magnetic particles is the difficulty in uniformly capturing magnetic particles, specifically the poor uniformity in the vicinity of channel side walls. This causes poor analysis accuracy and reproducibility. The present invention is intended to provide a means to uniformly capture magnetic particles in the vicinity of channel side walls. Specifically, the present invention provides an analysis device that includes a detection channel and a detector. The detection channel has an inlet and an outlet through which a sample liquid containing a specific substance and magnetic particles is flowed in and out of the channel, and magnetic field generating means capable of varying the magnitude of the magnetic field in a predetermined region of the detection channel. The width of the magnet in the detector is greater than the channel width. The detector can improve the analysis accuracy and reproducibility of the analysis device.